Registration Dossier
Registration Dossier
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EC number: 209-968-0 | CAS number: 599-64-4
Endpoint summary
Administrative data
Description of key information
In a skin irritation study performed per OECD Test Guideline 404 and EPA OPPTS 870.2500 the substance was non-irritating in the rabbit.
In an eye irritation study performed per OECD Test Guideline 405 the substance caused irreversible cornea, iris and conjunctival effects on the eye in the rabbit.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
The skin irritation potential was investigated in a study performed per OECD Test Guideline 404 and EPA OPPTS 870.2500 under GLP conditions (Toxikon Corporation, 2002).
Three New Zealand White rabbits were dosed with 0.5 g of the neat test substance under semi-occlusive conditions for 4 hours.
Under the conditions of this study, PCP is considered to be a non-irritant.
An additional non-GLP dermal irritation study (Hüls, 1988) following OECD Test Guideline 404 was conducted using 3 rabbits. The Primary Dermal Irritation Index was 2.78. All effects were resolved by the end of the study and p-Cumylphenol was considered a mild irritant.
Eye irritation
The key study was conducted according to OECD method 405 (Hüls, 1988).
Three Russian rabbits were dosed with 0.1 g of the neat test substance and the eyes were examined at 1, 24, 48 and 72 hours and 6, 8, 10, 13, 17 and 21 days after the application.
Under the conditions of this study, PCP is considered to cause irreversible effects to the eye. The effects of the test substance on the eye increased over the 21 day observation period, particularly in the cornea.
The supporting study was conducted per OECD 405 and EPA OPPTS 870.2400 under GLP conditions (Toxikon Corporation, 2002).
Three New Zealand White rabbits were dosed with 0.1 mL of PCP per eye. Eye irritation scores were recorded at 1, 24, 48 and 72 hours post-dose. Following the 24-hour observation, the treated eyes were rinsed.
Under the conditions of this study, PCP is considered to be a non-irritant to the eyes of rabbits.
Justification for classification or non-classification
In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No 1272/2008, the substance does not require classification with respect to skin irritation.
In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No 1272/2008, the substance does require classification with respect to eye irritation as Category 1 (H318: Causes serious eye damage).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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