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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 February 2018 to 24 February 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
Commission Regulation (EC) No 440/2008 of 30 May 2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Part A, A.6 Water Solubility
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for Testing of Chemicals, Guideline No. 105, "Water Solubility", adopted July 27, 1995
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Specific details on test material used for the study:
No further details specified in the study report.
Key result
Water solubility:
< 5.75 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
> 5.37 - < 5.69
Details on results:
The pH of the samples varied in the range of 5.37 – 5.69, the pH of control water samples varied in the range of 5.36 – 5.59.
Samples were analysed with the above NPOC method. The control samples were used for correction of the measured values of samples.
Based on the validation, the limit of quantification of NPOC method is 5 mg carbon/L. Assuming that the components of the test item are equally soluble in water, a theoretical limit of quantification can be given as 5.76 mg/L for the test item, as it is 86.87% carbon

Results of the determination of the test item concentrations

Measured carbon content after 1 day (mg/L)

pH

Measured carbon content after 2 day (mg/L)

pH

Measured carbon content after 3 day (mg/L)

pH

Solubility of the test item (mg/L)

<LOQ

5.41

<LOQ

5.61

<LOQ

5.37

<LOQ

<LOQ

5.46

<LOQ

5.48

<LOQ

5.41

<LOQ

5.39

<LOQ

5.69

<LOQ

5.54

 

Conclusions:
The carbon content of the soluble fraction of this UVCB substance was below the quantification limit (5 mg carbon/L) in each case. Considering, that the carbon content of test item is 86.87% based on the results of the elemental analysis, the water solubility of AMINOX® can be considered less as than 5.76 mg/L at 20°C.
Executive summary:

The purpose of this study was to determine the water solubility of AMINOX®, which is specified by the saturation mass concentration of the test item in water preferably at 20 ± 0.5 °C.

Although, as the expected water solubility is below 10-2 g/L, the flask method was applied because the column method is not suited to the NPOC analytical method.

 

Study performed in accordance with the following guidelines:

-Commission Regulation (EC) No 440/2008 of 30 May 2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Part A, A.6 Water Solubility

-Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for Testing of Chemicals, Guideline No. 105, "Water Solubility", adopted July 27, 1995

 

Considering, that the test item is an UVCB, without no signal chemical marker, the quantification of water solubility was made by the carbon content of the soluble fraction of test item was measured using a NPOC method. The carbon content of the soluble fraction of this UVCB substance was below the quantification limit (5 mg carbon/L) in each case. Considering, that the carbon content of test item is 86.87% based on the results of the elemental analysis, the water solubility of AMINOX® can be considered less than 5.75 mg/L at 20 °C, based on a theoretical calculation.

Description of key information

The water solubility of AMINOX® can be considered less than 5.75 mg/L at 20 °C, based on a theoretical calculation.

Key value for chemical safety assessment

Water solubility:
5.75 mg/L
at the temperature of:
20 °C

Additional information

The purpose of this study was to determine the water solubility of AMINOX®, which is specified by the saturation mass concentration of the test item in water preferably at 2 0± 0.5 °C.

Although, as the expected water solubility is below 10-2 g/L, the flask method was applied because the column method is not suited to the NPOC analytical method.

 

Considering, that the test item is an UVCB, without no signal chemical marker, the quantification of water solubility was made by the carbon content of the soluble fraction of test item was measured using a NPOC method. The carbon content of the soluble fraction of this UVCB substance was below the quantification limit (5 mg carbon/L) in each case. Considering, that the carbon content of test item is 86.87% based on the results of the elemental analysis, the water solubility of AMINOX® can be considered less than 5.75 mg/L at 20 °C, based on a theoretical calculation.