Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-000-3 | CAS number: 7783-48-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Genetic toxicity data are not available for strontium difluoride. However, studies conducted with soluble strontium and fluoride substances were included in the dossier. In conclusion no mutagenic / genotoxic effects were observed in relevant in vitro tests.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Reliable substance-specific information concerning the toxicity for strontium difluoride does not exist. Instead, toxicological information on fluorides (mainly sodium fluoride) substances and soluble inorganic strontium substances were extrapolated to strontium difluoride considering that the systemic effects mainly based on the concentrations of the Sr2+ and F- ions which are the key concern of strontium difluoride. For detailed read-across justification please refer to the report attached on IUCLID section 13 "SrF2_Read Across Assessment Framework Report"
Strontium:
Strontium did not induce micronuclei in cultured human peripheral blood lymphocytes following treatments in the absence and presence of an Aroclor induced rat liver metabolic activation system (S-9 mix). Concentrations were tested and analysed up to 2116 µg/mL.
Furthermore, it is concluded that strontium did not induce mutation at the tk locus of L5178Y mouse lymphoma cells when tested under the conditions employed in this study.
These conditions included treatments up to precipitating concentrations in two independent experiments, in the absence and presence of a rat liver metabolic activation system (S-9 mix).
Fluoride:
While both positive and negative results have been reported for fluoride in vitro, the reliable in-vivo studies indicate that fluoride salts do not interact directly with DNA and are not genotoxic when administered by an appropriate route of exposure.
Justification for classification or non-classification
Mutagenic / genotoxic effects were not observed in relevant in vitro tests with soluble inorganic strontium substances and fluorides (i.e., sodium fluoride). A similar conclusion is derived for strontium difluoride since potential effects would be regarded to as strontium-ion and fluoride-ion related effects. Hence, classification and labelling of strontium difluoride is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
