Registration Dossier
Registration Dossier
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EC number: 221-334-5 | CAS number: 3069-25-8
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Conclusion on classification
CONCLUSION ON CLASSIFICATION
Environmental fate and pathways
Water solubility
WS (parent) = 4.3E+05 mg/L (QSAR)
WS (silanol HP) = 1.0E+06 mg/L (QSAR)
Hydrolysis
DT50 (pH 7, 20 -25°C) = 2.8 h (QSAR)
Biodegradation
Not readily biodegradable (67% in 28 d, EU Method C.4 -A, DOC removal, RA from CAS 919-30-2)
Bioaccumulation
Log Kow (parent) = 0 (QSAR)
Log Kow (silanol HP) = -2.4 (QSAR)
Log Kow (methanol HP) = - 0.74 (OECD 2004)
Short-term aquatic toxicity
Fish
LC50 (96 h) > 100 mg/L (nominal, OECD 203)
Aquatic invertebrates
EC50 (48 h) > 100 mg/L (nominal, OECD 202)
Algae
EC50 (72 h) > 100 mg/L (nominal, OECD 201)
Long-term aquatic toxicity
Algae
NOEC (72 h) = 50 mg/L (nominal, OECD 201)
Conclusion on classification
N-methyl-3-(trimethoxysilyl)propylamine (CAS 3069-25-8) hydrolyses rapidly in water (estimated DT50 = 2.8 h) to the silanol hydrolysis product N-methyl-3 -(trihydroxysilyl)propylamine and methanol. The silanol hydrolysis product is not readily biodegradable. Acute toxicity data were available for all three trophic levels. No toxicity was observed in any trophic level up to the highest tested concentration of 100 mg/L. Since the substance hydrolyses rapidly, the test organisms were predominantly exposed to the hydrolysis products, which was analytically verified by appropriate methods.
On this basis, N-methyl-3-(trimethoxysilyl)propylamine is not classified as hazardous to the environment according to the Regulation (EC) No.1272/2008 (CLP) and further amendments (ATPs).
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