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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 December 2016 to 12 December 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance
Key result
Temp.:
25 °C
Vapour pressure:
0.001 Pa

The mean vapour pressure was 5 × 10^-4 Pa at 25 °C.

A visual assessment of the sample following testing confirmed that the test material had not undergone any changes.

Table 1: Summary of Results

 

Run 1

Run 2

Correlation 

-0.9986

-0.9969

Slope

-4223

-4720

Intercept

10.97

12.45

Log Vp at 25 °C

-3.20

-3.38

Vp (Pa) at 25 °C

6.4 x10^-4

4.1 x10^-4

 

Conclusions:
Under the conditions of this study the vapour pressure of the test material was found to be 5 × 10^-4 Pa at 25 °C.
Executive summary:

The vapour pressure of the test material was determined in accordance with the standardised guidelines OECD 104 and EU Method A.4 under GLP conditions using a vapour pressure balance.

The microbalance was calibrated with a UKAS calibrated 1 mg weight. It was found that 1 μg produced a deflection of 1.02 × 10^-3 V. A quantity of test material (1.0 g) was added to the furnace. The apparatus was then assembled and evacuated to a pressure of less than 1.0 × 10^-5 Torr (1.3 × 10^-3 Pa). After stabilisation at a given temperature, the shutter was opened to allow a stream of vapour to impact upon one balance pan. The temperature and pan deflection were recorded on a chart recorder. The trace obtained enabled the calculation of mass difference. The furnace temperature was then raised in steps of 5 °C and further measurements taken. Two runs were performed between temperatures of 43.5 and 83.5 °C. The same sample was used for each test, with the pressure being kept below 1.0 × 10^-5 Torr throughout the tests.

Under the conditions of the study the vapour pressure of the test material was found to be 5 × 10^-4 Pa at 25 °C.

Description of key information

Under the conditions of the study the vapour pressure of the test material was found to be 5 × 10^-4 Pa at 25 °C.

Key value for chemical safety assessment

Vapour pressure:
0.001 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure of the test material was determined in accordance with the standardised guidelines OECD 104 and EU Method A.4 under GLP conditions using a vapour pressure balance. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The microbalance was calibrated with a UKAS calibrated 1 mg weight. It was found that 1 μg produced a deflection of 1.02 × 10^-3 V. A quantity of test material (1.0 g) was added to the furnace. The apparatus was then assembled and evacuated to a pressure of less than 1.0 × 10^-5 Torr (1.3 × 10^-3 Pa). After stabilisation at a given temperature, the shutter was opened to allow a stream of vapour to impact upon one balance pan. The temperature and pan deflection were recorded on a chart recorder. The trace obtained enabled the calculation of mass difference. The furnace temperature was then raised in steps of 5 °C and further measurements taken. Two runs were performed between temperatures of 43.5 and 83.5 °C. The same sample was used for each test, with the pressure being kept below 1.0 × 10^-5 Torr throughout the tests.

Under the conditions of the study the vapour pressure of the test material was found to be 5 × 10^-4 Pa at 25 °C.

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