Trisodium 1-amino-4-[[3-[[4-chloro-6-[(sulphonatophenyl)amino]-1,3,5-triazin-2-yl]amino]-2,4,6-trimethyl-5-sulphonatophenyl]amino]-9,10-dihydro-9,10-dioxoanthracene-2-sulphonate

Endpoint summary

Description of key information

Biodegradation in water:

Estimation Programs Interface Suite (EPI suite, 2018) was run to predict the biodegradation potential of the test compound Trisodium 1-amino-4-[[3-[[4-chloro-6-[(sulphonatophenyl)amino]-1,3,5-triazin-2-yl]amino]-2,4,6-trimethyl-5-sulphonatophenyl]amino] -9,10-dihydro-9,10-dioxoanthracene-2-sulphonate (CAS no. 72214 -18 -7) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical  Trisodium 1-amino-4-[[3-[[4-chloro-6-[(sulphonatophenyl)amino]-1,3,5-triazin-2-yl]amino]-2,4,6-trimethyl-5-sulphonatophenyl]amino] -9,10-dihydro-9,10-dioxoanthracene-2-sulphonate is expected to be not readily biodegradable.

Additional information

Biodegradation in water:

Predicted data study for target chemical Trisodium 1-amino-4-[[3-[[4-chloro-6-[(sulphonatophenyl)amino]-1,3,5-triazin-2-yl]amino]-2,4,6-trimethyl-5-sulphonatophenyl]amino] -9,10-dihydro-9,10-dioxoanthracene-2-sulphonate (CAS no. 72214 -18 -7) has been conducted and experimental studies for its structurally similar read across chemicals have been reviewed from study report and their results are summarized below for biodegradation endpoint.

 

In a predicted data study for target chemical Trisodium 1-amino-4-[[3-[[4-chloro-6-[(sulphonatophenyl)amino]-1,3,5-triazin-2-yl]amino]-2,4,6-trimethyl-5-sulphonatophenyl]amino] -9,10-dihydro-9,10-dioxoanthracene-2-sulphonate (CAS no. 72214 -18 -7) the Estimation Programs Interface Suite (EPI suite, 2018) was run to predict the biodegradation potential of the test compound  Trisodium 1-amino-4-[[3-[[4-chloro-6-[(sulphonatophenyl)amino]-1,3,5-triazin-2-yl]amino]-2,4,6-trimethyl-5-sulphonatophenyl]amino] -9,10-dihydro-9,10-dioxoanthracene-2-sulphonate in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical   Trisodium 1-amino-4-[[3-[[4-chloro-6-[(sulphonatophenyl)amino]-1,3,5-triazin-2-yl]amino]-2,4,6-trimethyl-5-sulphonatophenyl]amino] -9,10-dihydro-9,10-dioxoanthracene-2-sulphonate is expected to be not readily biodegradable.

 

Next study is experimental study reviewed from study report (2016) in this study the 28-days Manometric respirometry test following the OECD guideline 301 F was performed to determine the ready biodegradability of the test chemical. The test system included control, test item and reference item. The concentration of test and reference item (Sodium Benzoate) chosen for the study was 20 mg/l and 30 mg/l, while that of inoculum was 10ml/l. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % Degradation was calculated using the values of BOD and ThOD for test item and reference item. The BOD28value of was observed to be 0.050mgO2/mg. ThOD was calculated as1.088 mgO2/mg. Accordingly, the % degradation of the test item after 28 days of incubation at 20 ± 1°C according to manometric respirometry test was determined to be 4.596 %. Based on the results, the test item, under the test conditions, was considered to be not readily biodegradable at 20 ± 1°C over a period of 28 days.

 

Another study is also experimental study reviewed from study report (2016) in this study 28-days Manometric respirometry test following the OECD guideline 301F to determine the ready biodegradability of the test chemical. The test system included control, test item and reference item. The concentration of test and reference item (Sodium Benzoate) chosen for both the study was 30 mg/L, while that of inoculum was 10 ml/l. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % Degradation was calculated using the values of BOD and ThOD for test item and reference item. The BOD28 value of test chemical was observed to be 0.022 mgO2sup>/mg. ThOD was calculated as 1.267 mgO2/mg. Accordingly, the % degradation of the test item after 28 days of incubation at 20 ± 1°C according to manometric respirometry test was determined to be 1.754 %. Based on the results, the test chemical, under the test conditions, was considered to be not readily biodegradable at 20 ± 1°C over a period of 28 days.

 

By considering results or all above mentioned study it can be concluded that target chemical Trisodium 1-amino-4-[[3-[[4-chloro-6-[(sulphonatophenyl)amino]-1,3,5-triazin-2-yl]amino]-2,4,6-trimethyl-5-sulphonatophenyl]amino] -9,10-dihydro-9,10-dioxoanthracene-2-sulphonate (CAS no. 72214 -18 -7) is expected to be not readily biodegradable.