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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental starting date : 4th May 2016 , experimental completion date 20th June 2017. Report date 13 October 2017.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
cascade impaction
Remarks on result:
not determinable because of methodological limitations
No.:
#1
Size:
< 100 µm
Distribution:
ca. 96.9 %
No.:
#2
Size:
< 10 µm
Distribution:
ca. 0.08 %
No.:
#3
Size:
< 5.5 µm
Distribution:
< 0.02 %
Conclusions:
Particle size data aquired for the test item is shown below.

Proportion of test item having an inhalable particle size < 100 um = 96.9% SIEVE
Proportion of test item having a thoracic particle size < 10.0 um = 0.08% Cascade Impactor
Proportion of test item having a repsirable particle size < 5.5 um = 0.02% Cascade Impactor
Executive summary:

Introduction

The study was carried out using a procedure designed to be compatible with that given in European commission guidance document EUR 20268 'determination of particle size distribution, fibre length, and diameter of chemical substances '(2002).

Method

Initially, sieving apparatus was used in a screening test using a 100um sieve. Then a cascade impactor was used to measure the particle size between 0.3 to 10um.Following the shaking period , the mass of the receiver pan was recorded and the percentage of test item with the particle size less than 100um was calculated.

Results

96.9% of the particles are less than the inhalable particle size 100 um. There were too few of the particles less than 10um to allow the accurate assessment of the mass aerodynamic diiameter.

Description of key information

96.9% of the test substance particles are less than the inhalable particle size 100 µm. There were too few of the particles less than 10 µm to allow the accurate assessment of the mass aerodynamic diiameter.

Additional information