Registration Dossier
Registration Dossier
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EC number: 203-319-5 | CAS number: 105-65-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Version / remarks:
- No variations
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Bis(isopropyl) thioperoxydicarbonate
- EC Number:
- 203-319-5
- EC Name:
- Bis(isopropyl) thioperoxydicarbonate
- Cas Number:
- 105-65-7
- Molecular formula:
- C8H14O2S4
- IUPAC Name:
- bis(isopropyl) thioperoxydicarbonate
- Test material form:
- solid: granular
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1:10 acetone:peanut oil
- Doses:
- 200mg/kg up to 3400mg/kg daily
- No. of animals per sex per dose:
- Not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 1 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- From 1500 mg/kg bw upwards
- Clinical signs:
- Discomfort, irritability, pallor, diarrhea, excessive water intake and urination for 40mg/kg up 1000mg/kg
- Body weight:
- Weight loss
- Gross pathology:
- Non below non-lethal doses but dehydration, liver injury, hemorrhagic gastritis at 3400 mg/kg and albumin in kidney at 2250 and 1500mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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