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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

Data for 2-(2-(2-ethoxyyethoxy)ethoxy)ethanol:
- Pimephales Promelas: LC50(96hrs) >10000mg/l.
- Carrassius auratus: LC50(24 hrs) >5000mg/l.
- QSAR prediction: LC50 = 32g/L
- QSAR prediction: LC50 = 73g/L

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
10 000 mg/L

Additional information

No data is available for the UVCB substance itself. A limited number of acute toxicity studies are available in fish for a major component of the substance, 2-(2-(2-ethoxyyethoxy)ethoxy)ethanol which show that it is practically non-toxic to fish. The LD50 was always in excess of the maximum tested dose. A reliable QSAR predicts that the LD50 of this substance is 32g/L and that the other major component, 3,6,9,12-tetraoxatetradecan-1-ol will be less toxic (LD50 73g/L). It therefore seems an acceptable conservative approach to use data from 2-(2-(2-ethoxyethoxy)ethoxy)ethanol in place of absent data for the UVCB substance itself.