Registration Dossier
Registration Dossier
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EC number: 310-288-2 | CAS number: 161907-78-4 A complex mixture of oxygenated hydrocarbons produced by the distillation of residues from the manufacture of ethylene glycol monoethyl ether. It consists predominantly of a mixture of di-, tri-, tetra- and pentaethylene glycol monoethyl ethers having carbon numbers predominantly in the range C6 to C12 and boiling in the range of approximately 200°C to 300°C (392°F to 572°F).
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Data for 2-(2-(2-ethoxyyethoxy)ethoxy)ethanol:
- Daphnia magna LC50 (48hr) >10000mg/l
- Artemia salina TLm (24hr) >10000mg/l
- QSAR prediction, 48hr EC50 = 14g/L
Data for 3,6,9,12-tetraoxatetradecan-1-ol:
- QSAR prediction, 48hr EC50 = 32g/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 10 000 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 10 000 mg/L
Additional information
No data is available for the UVCB substance itself. A limited number of acute toxicity studies are available in invertebrates for the a major component, 2-(2-(2-ethoxyyethoxy)ethoxy)ethanol ,which show that it is practically non-toxic to daphia and artemia (fresh and salt water species respectively). The LC50 was always in excess of the maximum tested dose. A reliable QSAR predicts that the LC50 of this substance will be 14g/L and that the LC50 of the other major component, 3,6,9,12-tetraoxatetradecan-1-ol, is significantly less toxic (LC50 =32g/L). It therefore seems an acceptable conservative approach to use data from t2-(2-(2-ethoxyethoxy)ethoxy)ethanol in place of absent data for the UVCB substance itself.
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