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Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on absorption rate: 
Permeability co-efficient: 24 +/-0.9ug/cm2/hr

Key value for chemical safety assessment

Additional information

No metabolism or toxicokinetic data is available for this UVCB substance. The main metabolic pathway for metabolism of ethylene glycol monoalkyl ethers is oxidation via alcohol and aldehyde dehydrogenases (ALD/ADH) that leads to the formation of an alkoxy acid. Alkoxy acids are the only toxicologically significant metabolites of glycol ethers that have been detected in vivo. Methoxy acetic acid, a metabolite of ethylene glycol methyl ether, is a known testicular toxicant in rats, and butoxyacetic acid, a metabolite of ethylene glycol butyl ether, causes hemolysis of rodent red blood cells. The principal metabolite of of the two main components of this substance, 3,6,9,12-tetraoxatetradecan-1-ol and 2-(2-(2-ethoxyethoxy)ethoxy)ethanol, are believed to be 3,6,9,12-tetraoxatetradecanoic acid and 2-(2-(2-ethoxyethoxy)ethoxy)ethoxy acetic acid, neither of which is expected to have any adverse toxicological properties. Although ethylene glycol, a known kidney toxicant, has been identified as an impurity or a minor metabolite of glycol ethers in animal studies, it does not appear to contribute to the toxicity of glycol ethers. Some glycol ethers have been shown to undergo conjugation with sulfate and glucuronic acid, and the alkoxyacetic acid metabolites may conjugate with glycine (rodents) or glutamine (humans). Conjugation is regarded as a pathway of detoxification.

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