Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1960

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The toxicity of the test item was accessed in mice by subcutaneous injection.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium pyruvate
EC Number:
204-024-4
EC Name:
Sodium pyruvate
Cas Number:
113-24-6
Molecular formula:
C3H4O3.Na
IUPAC Name:
sodium 2-oxopropanoate
Test material form:
solid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: subcutaneous injection
Vehicle:
not specified
Details on oral exposure:
The test item was applied by subcutaneous injection.
Doses:
Not specified
No. of animals per sex per dose:
Not specified
Control animals:
not specified
Details on study design:
Not specified
Statistics:
Not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 533 mg/kg bw
Based on:
test mat.
Mortality:
Not specified
Clinical signs:
other: Not specified
Gross pathology:
Not specified

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute toxicity of the test item was accessed in mice by subcutaneous injection. The LD50 was determined to be 3533 mg/kg bw.
Executive summary:

The acute toxicity of the test item was accessed in mice by subcutaneous injection. The LD50 was determined to be 3533 mg/kg bw.