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EC number: 615-063-5 | CAS number: 700863-48-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The acute toxicity of the test item was investigated in an acute and dermal toxicity study on rats. The test animals showed no clinical signs (and no mortality) up to the limit dose after oral or dermak administration. Hence, the LD50 is above 2000 mg/Kg bw.
The subsequent evaluation on the necessity of a acute test via a second route was done in accordance with Guidance on Information Requirements and Chemical Safety Assessment Chapter R.7a: Endpoint specific guidance, Version 6.0, July 2017, p 374f.
Based on the absence of systemic effects after acute oral and dermal administration, a study on acute inhalation toxicity is not required.
Furthermore, based on the lack of systemic toxicity after acute oral adminsitration, it is more than evident that an acute study on inhalation would not show any different outcome. Therefore, and due to animal welfare reasons a study on acute inhalation is not required.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
In an acute oral toxicity study, one group of fasted, young adult Wistar rats (3/sex) were given a single oral dose of the test substance with aqueous Methocel® K4M Premium solution (2.5 g/L) as vehicle at a dose of 2000 mg/kg bw and observed for 14 days.
Oral LD50:
Males > 2000 mg/kg bw
Females > 2000 mg/kg bw
Combined > 2000 mg/kg bw
No mortality occurred in this limit test.
The test subsance is of low Toxicity based on the LD50 in male and female rats.
There were no treatment related clinical signs, necropsy findings or changes in body weight.
Dermal route:
In an acute dermal toxicity study, one group of young adult Wistar rats (5 /sex) were dermally exposed to test substance in liquid paraffin for 24 hours to the shaven body surface area of 6 x 6 cm of at a limit dose of 2000 mg/kg bw. Animals then were observed for 14 days.
Dermal LD50:
Males > 2000 mg/kg bw
Females > 2000 mg/kg bw
Combined > 2000 mg/kg bw
No mortality occurred in this limit test.
the test substance is of low Toxicity based on male and female animals.
No signs of toxicity were detected in the rats (5 males and 5 females) after treatment with 2000 mg/kg. No deaths occurred during the course of the study. There were no treatment related clinical signs, necropsy findings or changes in body weight.
Justification for classification or non-classification
Based on the results for acute oral and dermal toxicity in rats, the
test substance
is considered to have no acute toxic potential. The expected LD50 values are higher than 2000 mg/kg bw after oral and after dermal administration to rats. Therefore, the
test substance
is not classified according to EU Regulation No.1272/2008.
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