1,2-bis(chloromethyl)benzene

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

other information

Study period:

1976-Oct-27 - 1976-Dec-30

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

acute toxic class method

Test material

Test material information

Specific details on test material used for the study:

Colourless crystalline material.

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: HOECHST AG, SPF-Zucht
- Weight at study initiation: 82 g - 108 g (average 93 g)
- Fasting period before study: 16 hours
- Diet: Altromin 1324 rat diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: sesam oil

Doses:

320, 500, 800, 1250, 2000 mg/kg bw

No. of animals per sex per dose:

10

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

603 mg/kg bw

Based on:

test mat.

95% CL:

>= 520 - 699

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The LD50 value for acute oral toxicity is 603 mg/kg bw in female Wistar rats.