Registration Dossier
Registration Dossier
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EC number: 251-889-9 | CAS number: 34231-26-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- BASF-Test
- GLP compliance:
- no
- Test type:
- other: BASF method
- Limit test:
- no
Test material
- Reference substance name:
- 1-amino-4-hydroxy-2-[(6-hydroxyhexyl)oxy]anthraquinone
- EC Number:
- 251-889-9
- EC Name:
- 1-amino-4-hydroxy-2-[(6-hydroxyhexyl)oxy]anthraquinone
- Cas Number:
- 34231-26-0
- Molecular formula:
- C20H21NO5
- IUPAC Name:
- 1-amino-4-hydroxy-2-[(6-hydroxyhexyl)oxy]-9,10-dihydroanthracene-9,10-dione
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- - Concentration in vehicle: 2% to 30%
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- No data
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes - Statistics:
- NA
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 4 300 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No mortality
- Clinical signs:
- other: None
- Gross pathology:
- No effects
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study in rats, the LD50 (gavage) value of the test item was reported to be greater than 5000 mg/kg bw (test mat.).
- Executive summary:
In an acute oral toxicity study according to BASF method, rats were given a single oral dose of the test item at a dose of 5000 mg/kg bw and were observed for 7 days. The LD50 was reported to be greater than 5000 mg/kg body weight.
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