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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
BASF internal testing method
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-amino-4-hydroxy-2-[(6-hydroxyhexyl)oxy]anthraquinone
EC Number:
251-889-9
EC Name:
1-amino-4-hydroxy-2-[(6-hydroxyhexyl)oxy]anthraquinone
Cas Number:
34231-26-0
Molecular formula:
C20H21NO5
IUPAC Name:
1-amino-4-hydroxy-2-[(6-hydroxyhexyl)oxy]-9,10-dihydroanthracene-9,10-dione
Test material form:
solid

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
yes, concurrent no treatment
Amount / concentration applied:
50 mg
Duration of treatment / exposure:
1 hour
Observation period (in vivo):
1, 24, 144 hours
Number of animals or in vitro replicates:
no data
Details on study design:
SCORING SYSTEM:
Draize

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24/48/72 h
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 96 h
Remarks on result:
probability of weak irritation
Irritation parameter:
iris score
Basis:
mean
Time point:
24/48/72 h
Score:
0.33
Max. score:
2
Reversibility:
fully reversible within: 96 h
Remarks on result:
probability of weak irritation
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
3
Remarks on result:
no indication of irritation
Irritation parameter:
chemosis score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
The substance causes slight reversible cornea opacity and inflammation on iris. All pathological findings and irritations were fully reversible within 4 days.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In this study, slight reversible cornea opacity and inflammation of the iris was observed. All pathological findings and irritations were fully reversible within 4 days. The substance is not classifiable.
Executive summary:

In a primary eye irritation study, the test material was applied to the rabbit eye. Animals were observed for 6 days. Slight reversible cornea opacity and inflammation of the iris was observed. All pathological findings and irritations were fully reversible within 4 days.