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EC number: 208-904-9 | CAS number: 546-56-5
No reliable toxicity to fish data are available for octaphenylcyclotetrasiloxane (CAS 546-56-5).
Testing is not required for the following reasons:
- The substance is highly insoluble in water, indicating that aquatic toxicity is unlikely to occur.
- It is technically not feasible to conduct an aquatic study due to the very low water solubility of the substance (<1E-05 mg/l (insoluble)) and very high log Kow (9.0). These values indicate that maintaining stable aqueous test solutions will be extremely difficult. Furthermore, once dissolved, the substance will have the tendency to adsorb onto the glassware under experimental conditions and onto dissolved organic matter in the natural environment.
- Above a log Kow of 6 short-term toxicity effects are not expected, because the very limited aqueous solubility prevents toxic concentrations being achieved in exposure media.
- The physicochemical properties and very high expected Koc value means that if the substance could enter a wastewater treatment plant in influent waste waters, it would partition mainly to sludge (a small proportion may be volatilised), with a negligible amount passing to water. The result is that exposure of freshwater or marine aquatic compartments is negligible.
- The substance has a large molecular size which can inhibit bioavailability by inhibiting the passage of the molecule through the cell membrane.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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