Registration Dossier
Registration Dossier
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EC number: 208-904-9 | CAS number: 546-56-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance is highly insoluble in water, hence indicating that aquatic toxicity is unlikely to occur
- other:
Reference
Description of key information
Key value for chemical safety assessment
Additional information
No reliable toxicity to aquatic invertebrates data are available for octaphenylcyclotetrasiloxane (CAS 546-56-5).
Testing is not required for the following reasons:
- The substance is highly insoluble in water, indicating that aquatic toxicity is unlikely to occur.
- It is technically not feasible to conduct an aquatic study due to the very low water solubility of the substance (<1E-05 mg/l (insoluble)) and very high log Kow (9.0). These values indicate that maintaining stable aqueous test solutions will be extremely difficult. Furthermore, once dissolved, the substance will have the tendency to adsorb onto the glassware under experimental conditions and onto dissolved organic matter in the natural environment.
- Above a log Kow of 6 short-term toxicity effects are not expected, because the very limited aqueous solubility prevents toxic concentrations being achieved in exposure media.
- The physicochemical properties and very high expected Koc value means that if the substance could enter a wastewater treatment plant in influent waste waters, it would partition mainly to sludge (a small proportion may be volatilised), with a negligible amount passing to water. The result is that exposure of freshwater or marine aquatic compartments is negligible.
- The substance has a large molecular size which can inhibit bioavailability by inhibiting the passage of the molecule through the cell membrane.
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