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EC number: 208-904-9 | CAS number: 546-56-5
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- See endpoint summary for justification of read-across
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 56 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Remarks:
- as earthworm weight
- Duration:
- 56 d
- Dose descriptor:
- EC10
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 56 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 28 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
Reference
Description of key information
NOEC, EC10 and EC50 (56-d): ≥1000, >1000 and >1000 mg/kg dwt (nominal), reproduction,Eisenia fetida
NOEC, LC50 (28-d): ≥1000 and >1000 mg/kg dwt (nominal), survival and growth (as weight),Eisenia fetida, read-across from an analogous substance, phenyl silsesquioxanes (EC 939-487-8) within the Reconsile Siloxanes Category.
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 556 mg/kg soil dw
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 556 mg/kg soil dw
Additional information
There are no data describing the long-term toxicity of the registration substance to soil macroorganisms. However, data are available within the Siloxanes Category for the analogue substance, phenyl silsesquioxanes (EC 939-487-8).
56-day NOEC, EC10 and EC50 values of ≥1000, >1000 and >1000 mg/kg dwt respectively, have been determined for the effects on the reproduction of Eisenia fetida, based on nominal concentrations. 28-day NOEC and LC50 values of ≥1000 and >1000 mg/kg dwt have been determined for the survival and growth (as weight) of Eisenia fetida, based on nominal concentrations. These results are equivalent to ≥556, >556 and >556 mg/kg dwt respectively, when normalised to 2% organic carbon content.
Effect concentration values have been reported in terms of nominal concentrations because the measured concentrations were within 80% of nominal.
Due to the potential volatility of the read-across substance, a stability trial under OECD 222 conditions was carried out prior to the above study.
The stability assessment was executed over a 56 day period using [14C] radiolabelled phenyl silsesquioxanes test substance. The trial was carried out under OECD 222 test conditions, in natural soil, but without test organisms.
The test substance was mixed into natural soil and chemical analysis was performed by taking triplicate soil cores from one of the treated replicates at Days 0, 3, 7, 14, 28, and 56 and analysed by liquid scintillation counting (LSC) and high-performance liquid chromatography with radiometric detection (HPLC-RAM).
The measured dosing stock concentration was 414 mg/kg dry weight soil.
The measured applied test concentration was 381 mg/kg dry weight soil.
The test substance was determined to be stable in natural soil. This was based on the material balance remaining at or above 100 % AR (103 -107% of applied radioactivity) and the HPLC distribution of radioactivity showing similar chromatographic profiles (83.6 to 88.2%) over the 56 day study.
Further details are reported in the stability assessment EPSR (Smithers, 2020).
Refer to Section 6.3 for further discussion.
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