Registration Dossier

Administrative data

Description of key information

In an acute oral toxicity study conducted according to OECD Test Guideline 423 and in compliance with GLP, the reported LD50 value for octaphenylcyclotetrasiloxane was >2000 mg/kg bw (HSRL, 2011).

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

In an acute oral toxicity test conducted according to OECD Test Guideline 423 and in compliance with GLP, the reported LD50 value for octaphenylcyclotetrasiloxane was >2000 mg/kg bw (HSRL, 2011). There were no deaths, adverse clinical signs, effects on body weight and no macroscopic abnormalities were noted at necropsy in any of the animals.

Justification for classification or non-classification

Based on the available acute oral toxicity test octaphenylcyclotetrasiloxane does not require classification for acute toxicity according to Regulation (EC) No. 1272/2008.