Registration Dossier

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
basic toxicokinetics, other
Remarks:
Toxicokinetik assumption
Type of information:
other: Toxicokinetik assumption
Adequacy of study:
weight of evidence
Objective of study:
other: Toxicokinetik assumption
Qualifier:
no guideline followed
Principles of method if other than guideline:
Toxicokinetik assumption

Description of key information

There are no experimental toxicokinetic data available for the substance and this statement is based on available data as physico-chemical data and toxicological data. The assumption was conducted based on the REACH ECHA “Guidance on information requirements and chemical safety assessment chapter R.7c” of the ECHA guidance document (Version 3.0, June 2017).

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

Estimation of accumulation:

In general substances with high log P values have long biological half-lives. Substances with log P values of 3 and less would be unlikely to accumulate with the repeated intermittent exposure patterns normally encountered in the workplace but may be accumulate if exposures are continuous.

m-phenylene di(acetate) has a log Pow of 1.87 and a high water solubility of 7.4 g/L.

The physicochemical properties of m-phenylene di(acetate) do not favour substantial accumulation.