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EC number: 271-559-8
CAS number: 68585-53-5
In an acute oral toxicity study according to OECD guideline 423 a
LD50 of above 2000 mg/kg bw was determined.
Summary of the results
between 5000 and 2000
The acute toxic class method according
to OECD guideline 423 was carried out involving a stepwise procedure
with the use of 2000 mg/kg bw as the starting dose in three young adult
(8 weeks old) female Wistar rats. No animal died in the first step at
2000 mg/kg bw dose level, so treatment with 2000 mg/kg bw was repeated
on further three female rats. No animal died in the second step, too, so
the test was finished, the stopping criteria of Annex 2d of OECD
Guideline No. 423 was met.
Animals were weighed, observed for
lethality and toxic symptoms for 14 days after the treatment. Gross
pathological examination was carried out 15th day after the treatment.
No mortality was observed at single
oral dose of 2000 mg/kg bw. In both treatment steps, no clinical
symptoms were observed on the day of the treatment and during the 14-day
observation period, the general state and behaviour of experimental
animals were normal. The body weight development was undisturbed in all
animals. All organs of the animals treated with 2000 mg/kg bw proved to
be free of treatment related gross pathological changes.
In conclusion, an LD50 of above 2000
mg/kg bw was determined.
Classification, Labelling, and Packaging
Regulation (EC) No 1272/2008
The available experimental test
data are reliable and suitable for classification purposes under
Regulation (EC) No 1272/2008. As a result the substance is considered
not to be classified for acute oral toxicity under Regulation (EC) No
1272/2008, as amended for the twelfth time in Regulation (EU) No
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