Fatty acids, tall-oil, compds. with triethanolamine

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

10 March 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Specific details on test material used for the study:

The surface tension of the test material was determined by OECD Test No. 115. It was concluded: The surface tension of a test solution at 90% of the test material saturation solubility in water and at 20°C was 35.0 mN/m. According to this, the test material is considered to be surface active.

Key result

Remarks on result:

not determinable

Remarks:

Direct measurement of the water solubility by OECD Test No. 105 could not be done due to surfactant properties of the test material.

Details on results:

PRELIMINARY TEST
- A test material aliquot of 0.10 grams was shaken after the addition of 100 mL of water. The resulting solution contained some solids, was milky, and exhibited surface foaming. The sample was observed after 72 hours at room temperature and exhibited the same characteristics.

DEFINITIVE TEST
- Samples from the flasks were removed after three days mixing. The samples were cloudy and could not be cleared by filtration (0.2 μm) or centrifugation (9000 rpm) or dilution up to 500 times.
- It is concluded that the test material is surface active and has a solubility of less than 1 g/L.

OBSERVATIONS
- No chemical instability was observed during the test. Indications of water insolubility and surfactant properties were observed.

CONCLUSIONS AND REQUEST FOR EXEMPTION
- The test material exhibits surfactant qualities (foaming, stable cloudy solution). Direct measurement of the water solubility by OECD Test No. 105 could not be done due to surfactant properties of the test material. This is consistent with the surface tension data provided by the Sponsor, after the OECD 105 testing was attempted.

Conclusions:

The test material exhibits surfactant qualities (foaming, stable cloudy solution). Direct measurement of the water solubility by OECD Test No. 105 could not be performed due to surfactant properties of the test material. This is consistent with the surface tension data provided by the Sponsor, after the OECD 105 testing was attempted.

Executive summary:

The water solubility of the test material was investigated in accordance with the standardised guideline OECD 105, under GLP conditions.

In the preliminary test, 0.10 grams of the test material was shaken after the addition of 100 mL of water. The resulting solution contained some solids, was milky, and exhibited surface foaming. The sample was observed after 72 hours at room temperature and exhibited the same characteristics.

In the definitive test, samples from the flasks were removed after three days mixing. The samples were cloudy and could not be cleared by filtration (0.2 μm) or centrifugation (9000 rpm) or dilution up to 500 times. It is concluded that the test material is surface active and has a solubility of less than 1 g/L.

The test material exhibits surfactant qualities (foaming, stable cloudy solution). Direct measurement of the water solubility by OECD Test No. 105 could not be performed due to surfactant properties of the test material. This is consistent with the surface tension data provided by the Sponsor, after the OECD 105 testing was attempted.

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Description of key information

The test material exhibits surfactant qualities (foaming, stable cloudy solution). Direct measurement of the water solubility by OECD Test No. 105 could not be performed due to surfactant properties of the test material. This is consistent with the surface tension data provided by the Sponsor, after the OECD 105 testing was attempted.

Key value for chemical safety assessment

Water solubility:

1 g/L

Additional information

The water solubility of the test material was investigated in accordance with the standardised guideline OECD 105, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

In the preliminary test, 0.10 grams of the test material was shaken after the addition of 100 mL of water. The resulting solution contained some solids, was milky, and exhibited surface foaming. The sample was observed after 72 hours at room temperature and exhibited the same characteristics.

In the definitive test, samples from the flasks were removed after three days mixing. The samples were cloudy and could not be cleared by filtration (0.2 μm) or centrifugation (9000 rpm) or dilution up to 500 times. It is concluded that the test material is surface active and has a solubility of less than 1 g/L.

The test material exhibits surfactant qualities (foaming, stable cloudy solution). Direct measurement of the water solubility by OECD Test No. 105 could not be performed due to surfactant properties of the test material. This is consistent with the surface tension data provided by the Sponsor, after the OECD 105 testing was attempted.