Registration Dossier

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Toxicokinetics and metabolism

In vitro glyoxal is presumably metabolized to oxalic acid via glycolic and glyoxylic acids in the rat liver and by haemoglobin (Kun, 1952 ; Francoeur & Denstedt, 1954 ; Hills and Berry, 1967).

It was reported that with glutathione, glyoxal is converted in vitro to S-glycoloyl-glutathione by means of glyoxalase I (no further details ; Racker, 1952).

The mode of action of glyoxal is likely to be related to the chemically reactive nature of glyoxal as it contains two stronly electrophylic groups. Glyoxal forms stable adducts with guanosine by reaction with the N-1 as well as with the exocyclic nitrogen of guanine (see section on genotoxicity in vitro).

Key value for chemical safety assessment

Additional information