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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
12.01. - 14.03.2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: OECD Guideline 113 (Thermal Stability)
Version / remarks:
1981 / preleminary test
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of glycyl-L-tyrosine hydrochloride and potassium chloride
EC Number:
947-659-9
Molecular formula:
C11H14N2O4 * HCl and KCl
IUPAC Name:
Reaction mass of glycyl-L-tyrosine hydrochloride and potassium chloride
Test material form:
solid

Results and discussion

Vapour pressureopen allclose all
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0 Pa
Key result
Test no.:
#3
Temp.:
50 °C
Vapour pressure:
0 Pa
Transition / decomposition
Key result
Transition / decomposition:
yes
Transition temp.:
>= 230 °C
Remarks on result:
other: At 230 °C the start of a further exothermic effect with an energy release of greater - 70 J/g which can be assigned to a decomposition of the test item was observed.

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the test item Reaction mass of glycyl-L-tyrosine hydrochloride and potassium chloride was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation
EC No. 440/2008 Method A.4. Vapour Pressure and OECD Test Guideline No. 104 (2006).

Temperature / °C Vapour pressure / Pa
20 5.9 ×10-7
25 1.2 ×10-6
50 3.1 ×10-5

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