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EC number: 201-782-8 | CAS number: 87-90-1
Endpoint summary
Administrative data
Description of key information
Two in vivo studies on both skin and eye irritation. Cyanuric acid is non-irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Isaac’s Farm, Litchfield, Illinois, USA
- Age at study initiation: Young adult
- Weight at study initiation: 2.34 - 3.13 kg
- Diet (e.g. ad libitum): Provided ad libitum
- Water (e.g. ad libitum): Provided ad libitum
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- physiological saline
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 500 mg
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: Dorsal surface
- Type of wrap if used: Latex rubber
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 72 hours
SCORING SYSTEM: Draize - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 8
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effect observed
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: No effect observed
- Irritant / corrosive response data:
- Slight irritation to one abraded site of one male animal was observed on the first day after exposure, while skins of the remaining five rabbits remained normal throughout the study.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Cyanuric acid is not irritating
Reference
Table 1: Primary skin irritation to rabbits -Individual irritation scores
Animal number |
Period (days) |
Erythema |
Edema |
||||||
RFI |
LBI |
LFA |
RBA |
RFI |
LBI |
LFA |
RBA |
||
01M01 |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
01M02 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01M03 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01F01 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01F02 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01F03 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
|
|
|
|
01M01 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01M02 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01M03 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01F01 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01F02 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01F03 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
The primary irritation index for this group of animals is 0.0 on a scale of 0.0 to 8.0. Slight irritation to one abraded site of one male animal was observed on the first day after exposure, while skins of the remaining five animals appeared normal throughout the study. One male rabbit showed slight irritation to one of the abraded sites on one day but the remaining five animals appeared normal throughout the study.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Isaac’s Farm, Litchfield, Illinois, USA
- Age at study initiation: Young adult
- Weight at study initiation: 2.40 – 2.93 kg
- Diet (e.g. ad libitum): Provided ad libitum
- Water (e.g. ad libitum): Provided ad libitum
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 82 ± 1 mg
- Duration of treatment / exposure:
- 72 hour(s)
- Observation period (in vivo):
- 24, 48 and 72 h
- Number of animals or in vitro replicates:
- 6
- Details on study design:
-
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: fluorescein - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0.3
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: No effect observed
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: No effects observed
- Irritant / corrosive response data:
- The average of the Draize scores for 24, 48 and 72 h was 0.3. All irritation had subsided by the third day after exposure. No corneal or iridal involvement was observed. Conjunctival erythema and oedema = not reported
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Cyanuric acid is not irritating to eyes
Reference
Table 1: Primary eye irritation to rabbits - individual irritation scores
Animal number |
Observation day |
Cornea |
Iris |
Conjunctivae |
Total |
Average of 24, 48, 72 h |
01M01 |
1 |
0 |
0 |
0 |
0 |
0.0 |
2 |
0 |
0 |
0 |
0 |
||
3 |
0 |
0 |
0 |
0 |
||
|
|
|
|
|
|
|
01M02 |
1 |
0 |
0 |
0 |
0 |
0.0 |
2 |
0 |
0 |
0 |
0 |
||
3 |
0 |
0 |
0 |
0 |
||
|
|
|
|
|
|
|
01M03 |
1 |
0 |
0 |
0 |
0 |
0.0 |
2 |
0 |
0 |
0 |
0 |
||
3 |
0 |
0 |
0 |
0 |
||
|
|
|
|
|
|
|
01F01 |
1 |
0 |
0 |
0 |
0 |
0.0 |
2 |
0 |
0 |
0 |
0 |
||
3 |
0 |
0 |
0 |
0 |
||
|
|
|
|
|
|
|
01F02 |
1 |
0 |
0 |
2 |
2 |
0.7 |
2 |
0 |
0 |
0 |
0 |
||
3 |
0 |
0 |
0 |
0 |
||
|
|
|
|
|
|
|
01F03 |
1 |
0 |
0 |
2 |
2 |
1.3 |
2 |
0 |
0 |
2 |
2 |
||
3 |
0 |
0 |
0 |
0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
In an in vivo skin irritation study (Branch 1990) 500 mg cyanuric acid was applied to the abraded skin of 6 New Zealand White rabbits under an occlusive patch for 24 hours. Animals were observed after removal of the patch up to 72 h. The average of the erythema and edema assessments for the 6 animals after 72 h was 0.0. Cyanuric acid was found to be non-irritating to the skin in rabbits.
Eye irritation
In an in vivo eye irritation study (Branch 1981) 82 mg (the 0.1 ml equivalent) of crude cyanuric acid was instilled into the conjunctival sac of albino rabbits. All signs of irritation had subsided by the third day.
Justification for classification or non-classification
In the in vivo skin and eye irritation studies cyanuric acid was non-irritant and therefore requires no classification under DSD or CLP
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