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EC number: 201-782-8 | CAS number: 87-90-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
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- Explosiveness
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- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
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- Stability: thermal, sunlight, metals
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- Dissociation constant
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
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- Nanomaterial aspect ratio / shape
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- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
- Biodegradation
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study not to GLP or guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Proposed guidelines for registering pesticides in the U.S.; Hazard Evaluation: Humans and domestic animals, Section 163.84-1 (43 FR 37388)
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Monosodium cyanurate monohydrate
- IUPAC Name:
- Monosodium cyanurate monohydrate
- Details on test material:
- - Name of test material: Monosodium cyanurate monohydrate
- Physical state: Solid granules
- Analytical purity: 99.36% (equivalent to 77.34% cyanuric acid)
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Toxicity testing: S. typhimurium: TA100|Spot test: S. typhimurium: TA1535, TA1537, TA97, TA98 and TA100|Plate incorporation test: S. typhimurium: TA1535, TA1537, TA97, TA98 and TA100
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 preparations from liver of Aroclor 1254-induced male Sprague-Dawley rats and Aroclor 1254-induced male CD-1 mice.
- Test concentrations with justification for top dose:
- Toxicity testing: 10 mg, 3mg, 1 mg, 0.2 mg, 0.04 mg and 0.01 mg of sample per plate for stock no. 2 and 10 mg per plate for stock no. 1.
Spot test: 25 mg per spot
Plate incorporation test: 10 mg, 3 mg, 1 mg, 0.2 mg, 0.04 mg and 0.01 mg of sample/plate
Controls
- Positive controls:
- yes
- Positive control substance:
- other: 2-nitrofluorene, benzo(a)pyrene, NaNO2, 2-aminoanthracene, 9-aminoacridine
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: In agar (plate incorporation)
Results and discussion
Test results
- Species / strain:
- other: Toxicity testing: S. typhimurium: TA100 Spot test: S. typhimurium: TA1535, TA1537, TA97, TA98 and TA100|Plate incorporation test: S. typhimurium: TA1535, TA1537, TA97, TA98 and TA100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Remarks:
- With metabolic activation: no cytotoxicity at concentrations ≤ 10 mg of sample per plate.Without metabolic activation: no cytotoxicity at concentrations ≤ 10 mg of sample per plate.
Any other information on results incl. tables
Table 1: Table for gene mutation assay with S9 activation
Concentration (mg/plate) |
Revertant Colonies / Plate (mean from 3 separate tests) |
|||
TA98 |
TA100 |
TA1535 |
TA1537 |
|
10 |
31.7 |
231 |
14.3 |
7.7 |
3 |
47.7 |
260.3 |
17.3 |
5.3 |
1 |
31.3 |
266.7 |
19.3 |
8.7 |
0.2 |
34.7 |
257.3 |
14 |
9.7 |
0.04 |
28 |
254 |
15.7 |
10.7 |
0.01 |
40 |
262.3 |
21.7 |
10.3 |
Positive Control |
1003 |
1863 |
509 |
270 |
Negative Control |
35.7 |
255.7 |
18.7 |
12.3 |
Table 2: Table for gene mutation assay without S9 activation
Concentration (mg/plate) |
Revertant Colonies / Plate (mean from 3 separate tests) |
|||
TA98 |
TA100 |
TA1535 |
TA1537 |
|
10 |
- |
294.7 |
23.7 |
10.3 |
3 |
- |
276.3 |
24 |
10.3 |
1 |
- |
279 |
21.7 |
8.7 |
0.2 |
- |
300.3 |
23.3 |
8 |
0.04 |
- |
279.3 |
19.7 |
6.7 |
0.01 |
- |
296.6 |
19 |
7.3 |
Positive Control |
- |
534 |
503 |
721 |
Negative Control |
- |
247.3 |
24.3 |
8 |
- not tested
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Cyanuric acid was not mutagenic towards Salmonella typhimurium test strains in plate incorporation or spot tests conducted with or without a rat microsomal activation system. No microbial toxicity was observed with or without microsomal activation.
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