Dipotassium bis[μ-[tartrato(4-)-O1,O2:O3,O4]]diantimonate(2-) , stereoisomer

Adsorption / desorption

Administrative data

Endpoint:

adsorption / desorption: screening

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance has a low octanol water partition coefficient and the adsorption potential of this substance is related to this parameter

the study does not need to be conducted because the substance and its relevant degradation products decompose rapidly

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

hydrolysis

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is readily biodegradable

Justification for type of information:

In accordance with Column 2 adaptation statement of REACH Annex VII, information requirement section 9.2.2., this study does not need to be conducted if the substance is readily biodegradable. Antimony potassium tartrate is considered readily biodegradable in aerobic condition.

Reason / purpose for cross-reference:

data waiving: supporting information

Cross-reference 2

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

partition coefficient

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Justification for type of information:

1. SOFTWARE: EPI Suite Version 4.11
2. MODEL (incl. version number): KOWWIN v.168
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL: O=C(C4O2)O[Sb]2(OC4C([O-])=O)=[Sb]1(OC3C([O-])=O)OC(C3O1)=O.[K+].[K+]

Guideline:

other: REACH Guidance on QSARs R.6

Principles of method if other than guideline:

Meylan, W.M. and P.H. Howard.  1995.  Atom/fragment contribution method for estimating octanol-water partition coefficients.  J. Pharm. Sci. 84: 83-92

Specific details on test material used for the study:

SMILES: O=C(C4O2)O[Sb]2(OC4C([O-])=O)=[Sb]1(OC3C([O-])=O)OC(C3O1)=O.[K+].[K+]

Key result

Type:

log Pow

Partition coefficient:

ca. -7.28

Remarks on result:

other: QSAR predicted value

KOWWIN predicted that Antimony potassium tartrate has a log Kow = -7.28

Conclusions:

For organic substances with a logKow value below 4.5 it is assumed that the affinity for the lipids of an organism is insufficient to exceed the bio-accumulation criterion.

Data source

Reference

Reference Type:

review article or handbook

Title:

Handbook of Chemical Property Estimation Methods

Author:

Lyman W.J., Reehl W.F. and Rosenblatt D.H.

Year:

1990

Bibliographic source:

American Chemical Society