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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Classification & Labelling & PBT assessment

PBT assessment

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Administrative data

PBT assessment: overall result

Type of composition:
legal entity composition of the substance
State / form:
solid: bulk
Reference substance:
PBT status:
the substance is not PBT / vPvB

The PBT assessment of N-Acetyl-DL-tryptophan (CAS 87-32-1) is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2014).


Based on experimental findings N-Acetyl-DL-tryptophan (CAS 87-32-1) is readily biodegradable (74.6% after 28 d, O2 consumption corrected for nitrification, 301 F). Thus, the substance does not meet the screening criterion for persistence and is therefore not P or vP.



The log Kow of N-Acetyl-DL-tryptophan (CAS 87-32-1) is very low (< -1.7, pH 7, 23 °C, OECD 107). Therefore, the substance does not meet the screening criterion for bioaccumulation and is therefore not B or vB.



The available aquatic effect concentration of N-Acetyl-DL-tryptophan (CAS 87-32-1) for chronic toxicity is ≥ 0.1 mg/L (algae) and is > 0.1 mg/L for acute toxicity (fish, aquatic invertebrates and algae). Furthermore, the substance is readily biodegradable and has a log Kow < 4.5. Therefore, the criteria set out in Annex XIII of Regulation (EC) No 1907/2006 are not met and the substance is not considered to meet the T criterion.

In conclusion, the substance is not PBT/vPvB.