Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-739-3 | CAS number: 87-32-1
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- N-Acetyl-DL-tryptophan
- Type of composition:
- legal entity composition of the substance
- State / form:
- solid: bulk
- Reference substance:
- N-Acetyl-DL-tryptophan
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The PBT assessment of N-Acetyl-DL-tryptophan (CAS 87-32-1) is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2014).
Persistence
Based on experimental findings N-Acetyl-DL-tryptophan (CAS 87-32-1) is readily biodegradable (74.6% after 28 d, O2 consumption corrected for nitrification, 301 F). Thus, the substance does not meet the screening criterion for persistence and is therefore not P or vP.
Bioaccumulation
The log Kow of N-Acetyl-DL-tryptophan (CAS 87-32-1) is very low (< -1.7, pH 7, 23 °C, OECD 107). Therefore, the substance does not meet the screening criterion for bioaccumulation and is therefore not B or vB.
Toxicity
The available aquatic effect concentration of N-Acetyl-DL-tryptophan (CAS 87-32-1) for chronic toxicity is ≥ 0.1 mg/L (algae) and is > 0.1 mg/L for acute toxicity (fish, aquatic invertebrates and algae). Furthermore, the substance is readily biodegradable and has a log Kow < 4.5. Therefore, the criteria set out in Annex XIII of Regulation (EC) No 1907/2006 are not met and the substance is not considered to meet the T criterion.
In conclusion, the substance is not PBT/vPvB.
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
