Registration Dossier
Registration Dossier
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EC number: 202-503-2 | CAS number: 96-37-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- Not applicable, calculated value
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The aquatic toxicity was estimated by a QSAR, the Petrotox computer model (v. 3.04). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism
- GLP compliance:
- no
- Remarks:
- The data were calculated by a computer model
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material:
No data - Analytical monitoring:
- not required
- Details on sampling:
- No data
- Vehicle:
- no
- Details on test solutions:
- No data
- Test organisms (species):
- Tetrahymena pyriformis
- Details on inoculum:
- No data
- Test type:
- other:
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No data
- Hardness:
- No data
- Test temperature:
- No data
- pH:
- No data
- Dissolved oxygen:
- No data
- Salinity:
- No data
- Nominal and measured concentrations:
- No data
- Details on test conditions:
- No data
- Reference substance (positive control):
- not required
- Key result
- Duration:
- 48 h
- Dose descriptor:
- other: EL50
- Effect conc.:
- 70.68 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Details on results:
- No data
- Results with reference substance (positive control):
- No data
- Reported statistics and error estimates:
- No data
- Validity criteria fulfilled:
- yes
- Conclusions:
- The estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for this substance is 70.68 mg/L based on growth inhibition
- Executive summary:
The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
The estimated protozoan,Tetrahymena pyriformis, 48-hr EL50 value for this substance is 70.68 mg/L based on growth inhibition.
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- Not applicable, calculated value
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The aquatic toxicity was estimated by a QSAR, the Petrotox computer model (v. 3.04). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism
- GLP compliance:
- no
- Remarks:
- The data were calculated by a computer model
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No data - Analytical monitoring:
- not required
- Details on sampling:
- No data
- Vehicle:
- no
- Details on test solutions:
- No data
- Test organisms (species):
- Tetrahymena pyriformis
- Details on inoculum:
- No data
- Test type:
- other:
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No data
- Hardness:
- No data
- Test temperature:
- No data
- pH:
- No data
- Dissolved oxygen:
- No data
- Salinity:
- No data
- Nominal and measured concentrations:
- No data
- Details on test conditions:
- No data
- Reference substance (positive control):
- not required
- Key result
- Duration:
- 48 h
- Dose descriptor:
- other: NOEL
- Effect conc.:
- 15.81 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Details on results:
- No data
- Results with reference substance (positive control):
- No data
- Reported statistics and error estimates:
- No data
- Validity criteria fulfilled:
- yes
- Conclusions:
- The estimated protozoan, Tetrahymena pyriformis, 48-hr NOEL value for this substance is 15.81 mg/L based on growth inhibition.
- Executive summary:
The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
The estimated protozoan,Tetrahymena pyriformis, 48-hr NOEL value for this substance is 15.81 mg/L based on growth inhibition.
Referenceopen allclose all
Description of key information
There is no data available for Methylcyclopentane. Data is available for Hydrocarbons, C6, isoalkanes, <5% n-hexane; hexane; Hydrocarbons, C5-C7, n-alkanes, isoalkanes, n-hexane rich; and Hydrocarbons, C6, n-alkanes, isoalkanes, cyclics, n-hexane rich. This data is used for read across to Methylcyclopentane.
The estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value is 70.68 mg/L based on growth inhibition, for Hydrocarbons, C6, isoalkanes, <5% n-hexane and the 48-hr NOEL is 15.81 mg/L for Hydrocarbons, C6, isoalkanes, <5% n-hexane.
Key value for chemical safety assessment
Additional information
There is no data available for Methylcyclopentane. Data is available for Hydrocarbons, C6, isoalkanes, <5% n-hexane; Hexane; Hydrocarbons, C5 -C7, n-alkanes, isoalkanes, n-hexane rich; and Hydrocarbons, C6, n-alkanes, isoalkanes, cyclics, n-hexane rich. This data is used for read across to Methylcyclopentane.
The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
The estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for iso-hexane is 70.68 mg/L based on growth inhibition and the 48-hr NOEL is 15.81 mg/L for Hydrocarbons, C6, isoalkanes, <5% n-hexane.
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