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Toxicity to microorganisms

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Endpoint:
activated sludge respiration inhibition testing
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
Not applicable, calculated value
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance
Justification for type of information:
A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across: supporting information
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model (v. 3.04). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material:
No data
Analytical monitoring:
not required
Details on sampling:
No data
Vehicle:
no
Details on test solutions:
No data
Test organisms (species):
Tetrahymena pyriformis
Details on inoculum:
No data
Test type:
other:
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Post exposure observation period:
No data
Hardness:
No data
Test temperature:
No data
pH:
No data
Dissolved oxygen:
No data
Salinity:
No data
Nominal and measured concentrations:
No data
Details on test conditions:
No data
Reference substance (positive control):
not required
Key result
Duration:
48 h
Dose descriptor:
other: EL50
Effect conc.:
70.68 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Details on results:
No data
Results with reference substance (positive control):
No data
Reported statistics and error estimates:
No data
Validity criteria fulfilled:
yes
Conclusions:
The estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for this substance is 70.68 mg/L based on growth inhibition
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.

The estimated protozoan,Tetrahymena pyriformis, 48-hr EL50 value for this substance is 70.68 mg/L based on growth inhibition.

Endpoint:
activated sludge respiration inhibition testing
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
Not applicable, calculated value
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance
Justification for type of information:
A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across: supporting information
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model (v. 3.04). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No data
Analytical monitoring:
not required
Details on sampling:
No data
Vehicle:
no
Details on test solutions:
No data
Test organisms (species):
Tetrahymena pyriformis
Details on inoculum:
No data
Test type:
other:
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Post exposure observation period:
No data
Hardness:
No data
Test temperature:
No data
pH:
No data
Dissolved oxygen:
No data
Salinity:
No data
Nominal and measured concentrations:
No data
Details on test conditions:
No data
Reference substance (positive control):
not required
Key result
Duration:
48 h
Dose descriptor:
other: NOEL
Effect conc.:
15.81 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Details on results:
No data
Results with reference substance (positive control):
No data
Reported statistics and error estimates:
No data
Validity criteria fulfilled:
yes
Conclusions:
The estimated protozoan, Tetrahymena pyriformis, 48-hr NOEL value for this substance is 15.81 mg/L based on growth inhibition.
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.

The estimated protozoan,Tetrahymena pyriformis, 48-hr NOEL value for this substance is 15.81 mg/L based on growth inhibition.

Description of key information

There is no data available for Methylcyclopentane. Data is available for Hydrocarbons, C6, isoalkanes, <5% n-hexane; hexane; Hydrocarbons, C5-C7, n-alkanes, isoalkanes, n-hexane rich; and Hydrocarbons, C6, n-alkanes, isoalkanes, cyclics, n-hexane rich. This data is used for read across to Methylcyclopentane.

The estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value is 70.68 mg/L based on growth inhibition, for Hydrocarbons, C6, isoalkanes, <5% n-hexane  and the 48-hr NOEL is 15.81 mg/L for Hydrocarbons, C6, isoalkanes,  <5% n-hexane.

Key value for chemical safety assessment

Additional information

There is no data available for Methylcyclopentane. Data is available for Hydrocarbons, C6, isoalkanes, <5% n-hexane; Hexane; Hydrocarbons, C5 -C7, n-alkanes, isoalkanes, n-hexane rich; and Hydrocarbons, C6, n-alkanes, isoalkanes, cyclics, n-hexane rich. This data is used for read across to Methylcyclopentane.

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.

The estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for iso-hexane is 70.68 mg/L based on growth inhibition and the 48-hr NOEL is 15.81 mg/L for Hydrocarbons, C6, isoalkanes, <5% n-hexane.