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EC number: 291-905-1
CAS number: 90506-43-7
In Experiment II in strain TA 1537 with S9 mix the positive
control did not reach the lower limit of the historical control data.
Since the deviation is rather small (82±8 colonies vs. 83) and the
threshold of thrice the number the corresponding solvent control was
exceeded by far (induction factor of 8.2) the test was considered to be
a reverse gene mutation assay in bacteria according to OECD guideline
471 (adopted 21 July 1997), Salmonella typhimurium strains TA 1535,
TA 1537, TA 98, TA 100, and the Escherichia coli strain WP2 uvrA were
exposed to Phosphoric acid, C12-18 alkyl esters, potassium salts in
water at the following concentrations in the absence and presence of
mammalian metabolic activation (rat liver S9 mix):
10; 33; 100; 333; 1000; 2500; and 5000 µg/plate
10; 33; 100; 333; 1000; and 2500 µg/plate
1; 3; 10; 33; 100; 333; and 1000 µg/plate
all remaining strains: 10;
33; 100; 333; 1000; 2500; and 5000 µg/plate
I was conducted using the plate incorporation method, experiment II
using the pre-incubation method.
test substance was tested up to cytotoxic concentrations. Toxic effects
were observed in all strains with and without metabolic activation,
based on reduced number of spontaneous revertants.
test item precipitated in the overlay agar in the test tubes from 333 to
5000 µg/plate in Experiment I and from 1000 to 5000 µg/plate in
reference mutagens were used as positive controls and showed a distinct
increase of induced revertant colonies.
substantial increase in revertant colony numbers of any of the five
tester strains was observed following treatment with Phosphoric acid,
C12-18 alkyl esters, potassium salts at any dose level, neither in the
presence nor absence of metabolic activation (S9 mix). There was also no
tendency of higher mutation rates with increasing concentrations in the
range below the generally acknowledged border of biological relevance.
conclusion, it can be stated that during the described mutagenicity test
and under the experimental conditions reported, the test item did not
induce gene mutations by base pair changes or frameshifts in the genome
of the strains used.
Phosphoric acid, C12-18 alkyl esters, potassium salts is considered to
be non-mutagenic in this Salmonella typhimurium and Escherichia
coli reverse mutation assay.
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