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EC number: 222-671-0 | CAS number: 3570-55-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 24 February 1987
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,3-bis((2-mercaptoethyl)thio)-1-propanethiol
- EC Number:
- 411-290-7
- EC Name:
- 2,3-bis((2-mercaptoethyl)thio)-1-propanethiol
- Cas Number:
- 131538-00-6
- Molecular formula:
- C7 H16 S5
- IUPAC Name:
- 2,3-bis((2-mercaptoethyl)thio)-1-propanethiol
- Test material form:
- solid - liquid: suspension
- Details on test material:
- - Lot/batch No.: B-DMPT-EC1-05/2010-F4/2
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Research Animals, Inc. Denver, Pennsylvania
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: at least 8 weeks
- Weight at study initiation: Males: 2.4-2.5 kg; Females: 2.2-2.6 kg
- Housing: Individually housed, suspended, stainless steel with wire mesh bottoms.
- Diet (e.g. ad libitum): Lab Rabbit Chow HF (Purina #5326), ad libitum (125 g/day, while on test)
- Water (e.g. ad libitum): Automatic watering system, ad libitum. Municipal water supply (Elizabethtown Hater Co.).
- Acclimation period: 30 days
- Method of randomisation in assigning animals to test and control groups: Animals were randomly placed in cages upon receipt, and were placed on study as available at the time of study initiation. Any animals considered unsuitable because of poor health or outlying body weights were excluded from selection.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Temperature: monitored and recorded twice daily.
- Humidity (%): Humidity: monitored and recorded daily.
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure:
- % coverage: approx. 10% of the body surface area.
- Type of wrap if used: A layer of 8-ply gauze was then wrapped around the animal to cover the application site. The animal was then wrapped in an impervious plastic sleeve designed to contain the test material without leakage or undue pressure. The sleeve was secured with tape and Elizabethan collars.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Following approximately 24 hours of exposure, the wrappings were removed and the test site wiped free of excess test material with dry
paper towels.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1.6 mL/kg
- Concentration (if solution): 1269 mg/mL
- Constant volume or concentration used: yes
- Duration of exposure:
- 24 h
- Doses:
- - 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Viability check:
Twice Daily
Observations of Pharmacologic and Toxicologic Signs
Approximately 1, 2 and 4 hours after dosing and daily thereafter for fourteen days.
C. Body weights:
Day -1(at time of clipping; weights used for calculation of doses).
Pre-test (just prior to dosing)
Days 7 and 14
- Necropsy of survivors performed: yes
- Clinical signs including body weight
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No Mortality observed
- Clinical signs:
- other:
- Body weight:
- other body weight observations
- Remarks:
- The majority of animals exhibited weight losses or no weight change at Day 7 and/or 14.
- Gross pathology:
- Gross postmortem observations were similar to those seen in control animals in this laboratory or were considered to represent normal physiological variation.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the present study 4-mercaptomethyl-3,6-dithia-1,8-'octanedithiol was dermally administered to 10 New Zealand White rabbits (male/female) at a concentration of 2000 mg/kg bw. All animals survived throughout the study. The majority of animals exhibited weight losses or no weight change at Day 7 and/or 14. No significant dermal or systemic toxicity was seen throughout the study, although one animal exhibited ocular redness, discharge and opacity throughout the study. Gross postmortem observations were similar to those seen in control animals in this laboratory or were considered to represent normal physiological variations.Therefore, the dermal LD50 of the test item in rabbits is greater than 2000 milligrams per kilogram of body weight.
- Executive summary:
In an acute dermal toxicity study according to OECD test guideline 402 (1987), groups of young adult New Zealand White rabbits (5/sex) were dermally exposed to 2,3-bis((2-mercaptoethyl)thio)-1-propanethio for 24 hours to 10 % of the body surface area at a dose 2000 mg/kg bw. Animals then were observed for 14days.
Limit test
2,3-bis((2-mercaptoethyl)thio)-1-propanethiol is of low Toxicity based on the obtained results. No animal died during the Study and clinical signs were only marginal and reversible except for one male animal, thus a LD50 value could not be determined.
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