Registration Dossier
Registration Dossier
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EC number: 208-080-0 | CAS number: 507-70-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
- Principles of method if other than guideline:
- The precise methodology for exposure and measurement of bornan-2-one has been described in Camphor Poisoning Abuse of Camphor as a Stimulant
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Bornan-2-one
- EC Number:
- 200-945-0
- EC Name:
- Bornan-2-one
- Cas Number:
- 76-22-2
- Molecular formula:
- C10H16O
- IUPAC Name:
- 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- human
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
6-10g
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The plasma protein binding was determined by ultrafiltration with Zentriflow membranes of Amicon Inc. (Ryan and Hanna 1971; Vohland and Streichert 1978). A correction had to be made for the adsorption of camphor at the membrane. The protein binding was 61±6% at a concentration of 10 μg camphor/ml plasma.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Metabolite Ret. time ((min: sec)) Mass fragments m/e (intensity %)
I 5-hydroxycamphor 5 : 34 M + 168 (48), 153 (29), 135 (6), 125 (48), 111(100), 109 (31)
II 5-ketocamphor 3 : 10 M + 166 (96), 151 (14), 138 (12), 109 (79), 95(48), 69 (100)
III 9-hydroxycamphor 7 : 51 M + 168 (19), 153 (38), 135 (7), 125 (13), 111(28), 109 (31), 108 (100), 107 (53)
IV 8-hydroxycamphor 6 : 50 M + 168 (19), 153 (4), 137 (15), 109 (18), 108(53), 95 (100)
V 3-hydroxycamphor 4 : 55 M + 168 (9), 153 (91), 135 (13), 108 (93), 107(100), 93 (60)
VI 8 or 9-camphor carbonic acidtrimethylsilylester 7 : 17 M + 254 (6), 239 (8), 226 (4), 225 (4), 108 (58), 93(19), 73 (100)
VII Isoborneole 1 : 10 M + 154 (1), 139 (8), 136 (6), 121 (7), 110 (20), 95(100), 93 (11)
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
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