Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 227-642-6 | CAS number: 5919-74-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Morphological Changes of Rabbit Skin by Application of Dentin Primer
- Author:
- Manabe A. et. al.
- Year:
- 1 990
- Bibliographic source:
- Dental Materials Journal 9 (2): 147-152, 1990
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,3-dihydroxypropyl methacrylate
- EC Number:
- 227-642-6
- EC Name:
- 2,3-dihydroxypropyl methacrylate
- Cas Number:
- 5919-74-4
- Molecular formula:
- C7H12O4
- IUPAC Name:
- 2,3-dihydroxypropyl 2-methylprop-2-enoate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 62 months
- Weight at study initiation: approx. 2 kg
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- TtEST MATERIAL
- Amount(s) applied (volume or weight with unit): 30 µL
- Concentration (if solution): 25 and 35 wt% in water
- Duration of treatment / exposure:
- twice daily for 7 days
- Observation period:
- 7 days
- Details on study design:
- 30 µL of the dentin primers was applied twice a day for 7 days to the shaved skin of white rabbits. Twenty min after the final application, 3 of the rabbits were sacrificed to examine possible pathological changes and the others were sacrificed after an additional 7 days without primer application in order to observe any recovery in cutaneous changes.
Results and discussion
In vivo
Results
- Remarks on result:
- other: no obvious changes were recognized
- Other effects:
- No morphological changes were observed in the shaved skin of rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria are not met, no classification required according to Regulations (EC) No 1272/2008.
- Conclusions:
- No morphological changes were observed in the shaved skin of rabbits after repeated application of GM solution.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
