1-(carboxylatomethyl)methylpyridinium

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2018-04-09 to 2018-06-25

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

gas saturation method

Key result

Temp.:

20 °C

Vapour pressure:

0 Pa

Temp.:

40 °C

Vapour pressure:

0 Pa

Preliminary test: The obtained concentration at 20 mL/min was 5.05 mg/L, at 40 mL/min was 6.03 mg/L and at 60 mL/min was 2.40 mg/L.

Definitive test: The obtained concentration at 20 °C was 5.28 mg/L and at 40 °C was 6.25 mg/L, respectively. The vapour pressure for the test item at 20 °C was determined to be 0.25 mPa (0.00025 Pa) and at 40 °C was 0.31 mPa (0.00031 Pa), respectively.

Table 1. Determination of the vapour pressure at 20 °C

Flow Rate (mL/min)	Sample Code	Sample Peak Area	Slope	Intercept	Dilution Factor	Conc. Obtained      (mg/L)	Mean Conc. Obtained (mg/L)	(W) Mass of Evaporated Test Item (g)
40	Sample C1 R1 -Rep1	181027	618518.43	15735.98	20	5.34	5.28	0.000005340
	Sample C1 R1 -Rep2	180759	618518.43	15735.98	20	5.34		0.000005340
	Sample C1 R2 -Rep1	178589	618518.43	15735.98	20	5.27		0.000005270
	Sample C1 R2 -Rep2	178636	618518.43	15735.98	20	5.27		0.000005270
	Sample C1 R3 -Rep1	176389	618518.43	15735.98	20	5.19		0.000005190
	Sample C1 R3 -Rep2	178771	618518.43	15735.98	20	5.27		0.000005270

Table 2. Determination of the vapour pressure at 40 °C

Flow Rate (mL/min)	Sample Code	Sample Peak Area	Slope	Intercept	Dilution Factor	Conc. Obtained      (mg/L)	Mean Conc. Obtained (mg/L)	(W) Mass of Evaporated Test Item (g)
40	Sample C2 R1 -Rep1	211012	618518.43	15735.98	20	6.31	6.25	0.000006310
	Sample C2 R1 -Rep2	211239	618518.43	15735.98	20	6.32		0.000006320
	Sample C2 R2 -Rep1	208513	618518.43	15735.98	20	6.23		0.000006230
	Sample C2 R2 -Rep2	208710	618518.43	15735.98	20	6.24		0.000006240
	Sample C2 R3 -Rep1	207084	618518.43	15735.98	20	6.19		0.000006190
	Sample C2 R3 -Rep2	207273	618518.43	15735.98	20	6.19		0.000006190

Conclusions:

The vapour pressure of the test item was determined to be 0.25 mPa (0.00025 Pa) at 20 °C and 0.31 mPa (0.00031 Pa) at 40 °C, respectively.

Executive summary:

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined using the gas saturation method. A preliminary test with three different nitrogen flow rates (20, 40 and 60 mL/min) at 40 °C was performed. As no significant change in the concentration at the different flow rates was observed, 40 mL/min was selected as a flow rate for the definitive test. Three samples at 20 °C and three samples at 40 °C were maintained at the test temperature for 6 days. At the end of the test the trapping agent was collected and the test item was extracted with 5 mL diluent. The extract was measured with HPLC-UV to determine the test items concentration. The obtained concentration in the definitive test was 5.28 mg/L at 20 °C and 6.25 mg/L at 40 °C, respectively. The vapour pressure was calculated to be 0.25 mPa (0.00025 Pa) at 20 °C and 0.31 mPa (0.00031 Pa) at 40 °C.

Description of key information

The vapour pressure of the test item was determined to be 0.25 mPa (0.00025 Pa) at 20 °C and 0.31 mPa (0.00031 Pa) at 40 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

20 °C

Additional information

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined using the gas saturation method. A preliminary test with three different nitrogen flow rates (20, 40 and 60 mL/min) at 40 °C was performed. As no significant change in the concentration at the different flow rates was observed, 40 mL/min was selected as a flow rate for the definitive test. Three samples at 20 °C and three samples at 40 °C were maintained at the test temperature for 6 days. At the end of the test the trapping agent was collected and the test item was extracted with 5 mL diluent. The extract was measured with HPLC-UV to determine the test items concentration. The obtained concentration in the definitive test was 5.28 mg/L at 20 °C and 6.25 mg/L at 40 °C, respectively. The vapour pressure was calculated to be 0.25 mPa (0.00025 Pa) at 20 °C and 0.31 mPa (0.00031 Pa) at 40 °C.