Registration Dossier
Registration Dossier
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EC number: 945-453-3 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibition of the degradation activity of activated sludge is not anticipated when the target substance MCHAmix (EC 943 -5175 -5) is introduced in appropriately low concentrations.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 188 mg/L
- EC10 or NOEC for microorganisms:
- 138 mg/L
Additional information
There are no experimental data on the acute toxicity of the reaction product of 2,4-Dinitrotoluene and 2.6-Dinitrotoluene and hydrogen, deaminated (MCHAmix, EC 943-517-5) to aquatic microorganism. Therefore read-across approach was applied to the structurally similar substance 2,6-dimethylcyclohexylamine (CAS 6850-63-1).
Two studies are available for the source substance. One study was conducted according the German Industrial Standard DIN38412, part 8 with Pseudomonas putida. The 17-h EC10 value was 138 mg/L, the 17 -h EC50 was 188 mg/L (BASF AG, 1987, Rep.no.: 9/00306/87).
The supporting study was performed according to ISO 8192. Industrial activated sludge was used as an inoculum. The 30-min EC20 value was above 659 mg/L (BASF AG, 1987, Rep.no.: 01.269/87).
It can be concluded that the inhibition of the degradation activity of activated sludge is not anticipated when the target substance MCHAmix (EC 943 -5175 -5) is introduced in appropriate low concentrations.
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