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Description of key information

In an in vivo skin irritation test in guinea pig, the test item was applied to depilated skin for 24 h under occlusive conditions. A visual inspection revealed slight irritation of the skin area.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Qualifier:
no guideline followed
GLP compliance:
not specified
Species:
guinea pig
Strain:
not specified
Type of coverage:
occlusive
Preparation of test site:
other: depilated
Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
24 h
Irritation parameter:
other: visual inspection
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
not determinable because of methodological limitations
Interpretation of results:
other: No irritation expected under normal exposure conditions. Animals in this test were exposed for 24 hours under an occlusive dressing und only showed slight irritation.

Additional information

In an in vivo skin irritation test in guinea pig, the test item was applied to depilated skin for 24 h under occlusive conditions. A visual inspection revealed slight irritation of the skin area. No irritation is expected under normal exposure conditions. Animals in this test were exposed for 24 hours under an occlusive dressing und only showed slight irritation.

Justification for classification or non-classification

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