Registration Dossier
Registration Dossier
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EC number: 946-756-3 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Aliphatic Carboxylic Acids
- Author:
- Katz, G.V. and Guest, D.
- Year:
- 1 994
- Bibliographic source:
- cited in: Patty"s Industrial Hygiene and Toxicology (G.D. Clayton, F.E. Clayton, eds.), Vol. II, Part E, 3523-3671, John Wiley & Sons, N.Y., 1994
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Linoleic acid
- EC Number:
- 200-470-9
- EC Name:
- Linoleic acid
- Cas Number:
- 60-33-3
- Molecular formula:
- C18H32O2
- IUPAC Name:
- octadeca-9,12-dienoic acid
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: depilated
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- 24 h
Results and discussion
In vivo
Results
- Irritation parameter:
- other: visual inspection
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- not determinable because of methodological limitations
Applicant's summary and conclusion
- Interpretation of results:
- other: No irritation expected under normal exposure conditions. Animals in this test were exposed for 24 hours under an occlusive dressing und only showed slight irritation.
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