Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 946-756-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reference substance 001
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: inhouse breeding
- Housing: individually after confirmation of pregnancy
- Age at study initiation: adult, 110 days
- Diet: standard purified control diet (CD), standard purified control diet with c9,t11-CLA (CLA), high fat diet (HF), HF with c9,t11-CLA (HFCLA)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 25
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- P0 females: 160 days
F1: 150 days - Frequency of treatment:
- Daily
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 other: %
- Remarks:
- control diet (CD)
- Dose / conc.:
- 0 other: %
- Remarks:
- high fat diet (HF)
- Dose / conc.:
- 1 other: %
- Remarks:
- control diet with c9,t11-CLA (CLA)
- Dose / conc.:
- 1 other: %
- Remarks:
- HF with c9,t11-CLA (HFCLA)
- No. of animals per sex per dose:
- 7 dams
8 pups/litter - Control animals:
- yes, plain diet
- Details on study design:
- Female rats were fed for 10 days prior to time mated. Mating point was determined using a estrous cycle monitor (EC-40; Fine Science Tools).
- Statistics:
- Statistical analysis was performed using SigmaPlot 12.0 (Systat Software Inc.). All data were analyzed by two-way factorial ANOVA, with maternal HF and maternal CLA intake as factors. Holm-Sidak post hoc tests were performed where indicated to detect further differences between groups.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Remarks on result:
- other: no treatment related adverse effects were observed.
Observed effects
HF offspring had significantly increased plasma leptin concentrations compared to CD, CLA, and HFCLA offspring. Triglyceride as well as cholesterol concentrations were significantly increased in HF compared to CD, CLA, and HFCLA fed animals. An significant increase in hepatic IGF-1 expression in HF-offsprings at P24 was observed compared to all other groups, but no significant differences were observed at P150. IL-1b and IL-6 expression was increased in HF-offsprings compared to all other groups. However, there was no difference between groups in TNFa or IL-10 expression. CD36, DGAT1, and FASN were significantly upregulated in offspring of HF mothers compared with CD, CLA, and HFCLA offspring. ApoE was significantly increased in HF and HFCLA compared to CD and CLA groups. Female HF-offsprings showed prolonged or irregular estrous cycles compared to CD, CLA, and HFCLA groups.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
