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EC number: 257-473-3 | CAS number: 51851-37-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997-05-12 to 1997-05-30
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane
- EC Number:
- 257-473-3
- EC Name:
- Triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane
- Cas Number:
- 51851-37-7
- Molecular formula:
- C14H19F13O3Si
- IUPAC Name:
- triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane
- Reference substance name:
- [2-(Perfluorohexyl)ethyl]triethoxysilane
- IUPAC Name:
- [2-(Perfluorohexyl)ethyl]triethoxysilane
- Test material form:
- liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wistar rats (HsdCpb:WU / SPF) from Harlan Winkelmann GmbH, Gartenstraβe 27, 33176 Borchen.
- Age at study initiation: young adult animals
- Weight at study initiation: weight variation did not exceed ±20% of the mean body weight
- Fasting period before study: about 16 hours
- Housing: groups of max. five rats in Makrolon type III cages, sexes separated
- Diet (e.g. ad libitum): Ssniff R diet in pellet form (laboratory standard rat diet) ad libitum; ad libitum 3 hours after application
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3°C
- Humidity (%): 30-70%
- Air changes (per hr): no information in report
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- In the first instance 3 male rats were given a single oral application of the test substance at a dose level of 2000 mg/kg bw. Since no mortalities occurred within 24 hours p.a., 3 female rats were treated in the same way
MAXIMUM DOSE VOLUME APPLIED: 2000 mg/kg bw - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 males and 3 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed soon after dosing and at frequent intervals for the remainder of day 0 (a period of approximately 6 hours). On subsequent days animals were observed once a day. That nature and severity of the clinical signs were recorded at each observation. Individual body weights were recorded on days 0 (prior to dosing), 7 & 14
- Necropsy of survivors performed: animals were killed on day 14 by CO2 inhalation and subjected to a macroscopic examination after opening the abdominal and thoracic cavities. The macroscopic appearance of all examined tissues was recorded for each animal
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No rats died following a single oral application at 2000 mg/kg bw.
- Clinical signs:
- other: There were no deaths and no signs of systemic reaction to treatment.
- Gross pathology:
- No abnormalities.
- Other findings:
- Macroscopic examination: No macroscopic findings.
Any other information on results incl. tables
Acute oral toxicity study: body weights
Dose |
Body weight (g) on day |
Body weight gains (g) |
Body weight (g) on day |
Body weight gains (g) |
|||||||
Animal Number |
Substance mg/kg bw |
0 |
7 |
14 |
Week 1 |
Week 2 |
0 |
7 |
14 |
Week 1 |
Week 2 |
males |
females |
||||||||||
1 |
2000 |
148 |
210 |
248 |
62 |
38 |
134 |
160 |
169 |
26 |
9 |
2 |
2000 |
155 |
214 |
252 |
59 |
38 |
144 |
175 |
192 |
31 |
17 |
3 |
2000 |
152 |
204 |
246 |
52 |
42 |
136 |
161 |
161 |
25 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- [2-(Perfluorohexyl)ethyl]triethoxysilane has been tested in an acute oral toxicity study conducted according to OECD 423 and in compliance with GLP. The undiluted test substance was administered by gavage to a group of 3 male and 3 female rats. The rats were dosed at 2000 mg/kg bw. There were no deaths and no signs of systemic reaction to treatment. All animals achieved satisfactory bodyweight gains throughout the study. The LD50 was determined to be >2000 mg/kg bw.
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