Registration Dossier

Administrative data

Description of key information

The following key studies including 2 study reports have been selected to determinate the acute toxicity of 1-bromo-3-chloropropane :
- acute oral toxicity in the rat (Denton S.M.)
- acute dermal toxicity in the rat (Denton S.M.)
- characteristics of the General Toxic, Gonadatropic, and Mutagenic Effects of 1,3-chlorobromopropane (Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv)

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
1 100 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
7.27 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Justification for classification or non-classification

Under the experimental conditions, 1-bromo-3-chloropropane does require labelling with the hazard statement H302 "Harmful if swallowed" and H331 "Toxic if inhaled" in accordance with the CLP regulation.