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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data taken from IUCLID4 report with no information on methods or GLP status.

Data source

Reference
Reference Type:
review article or handbook
Title:
Characteristics of the General Toxic, Gonadatropic, and Mutagenic Effects of 1,3-chlorobromopropane
Author:
Eytingon, A.I.
Year:
1971
Bibliographic source:
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv, No. 12, p. 93-100

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No guideline mentioned in data source.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1-bromo-3-chloropropane
EC Number:
203-697-1
EC Name:
1-bromo-3-chloropropane
Cas Number:
109-70-6
Molecular formula:
C3H6BrCl
IUPAC Name:
1-bromo-3-chloropropane

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation: vapour
Vehicle:
air
Duration of exposure:
4 h
Details on study design:
Concentration analysis of air samples was performed by the method of F.D. Krivoruchko (1967)

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LC50
Effect level:
7.27 mg/L air
Based on:
test mat.
95% CL:
>= 7 - <= 7.55
Exp. duration:
4 h
Remarks on result:
other: LC16 was 8,6 mg/liter and LC84 was 7,8 mg/liter
Sex:
male
Dose descriptor:
LC50
Effect level:
6.5 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Clinical signs:
other: Clinical signs were similar to those seen in the oral studies.
Other findings:
Necropsy findings included congestion of internal organs and pulmonary hemorrhages. Microscopic examination revealed fatty degeneration of the liver and albuminoid degeneration of the kidneys. Congestion and irritation of the bronchial mucosa, fatty degeneration of the heart, and edema and swelling of neural tissue of the brain were seen.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
1-bromo-3-chloropropane does require labelling with the hazard statement H331 "Toxic if inhaled" in accordance with the CLP regulation. In addition, the description of the clinical signs in airway (nasal discharge, wheezing, ...) indicates a respiratory irritation potential of the substance in accordance with the annex 1 (chapter 3.8.2.2.1 d) of the CLP regulation.