Registration Dossier
Registration Dossier
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EC number: 203-697-1 | CAS number: 109-70-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data taken from IUCLID4 report with no information on methods or GLP status.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Characteristics of the General Toxic, Gonadatropic, and Mutagenic Effects of 1,3-chlorobromopropane
- Author:
- Eytingon, A.I.
- Year:
- 1 971
- Bibliographic source:
- Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv, No. 12, p. 93-100
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No guideline mentioned in data source.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-bromo-3-chloropropane
- EC Number:
- 203-697-1
- EC Name:
- 1-bromo-3-chloropropane
- Cas Number:
- 109-70-6
- Molecular formula:
- C3H6BrCl
- IUPAC Name:
- 1-bromo-3-chloropropane
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- other: tail skin
- Details on exposure:
- 4-hours exposure time
Results and discussion
- Mortality:
- Four hour exposure of mice to test article via the tail did not cause deaths within a 14 day observation period.
- Clinical signs:
- Pronounced hyperemia of the tail skin was observed, progressing to necrosis on the second or third day, followed by sloughing of the necrotic tissue.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this test (exposure via the tail), it is not possible to conclude on the acute toxicity of 1-bromo-3-chloropropane in accordance with the CLP regulation.
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