Registration Dossier

Administrative data

Description of key information

The following key studies containing 2 study reports have been selected to determinate the skin, eye and respiratory irritation of 1-bromo-3-chloropropane :
- skin irritation to the rabbit (Liggett M.P.)
- eye irritation to the rabbit (Liggett M.P.)
- Characteristics of the General Toxic, Gonadatropic, and Mutagenic Effects of 1,3-chlorobromopropane
- Primary Dermal Irritation Compound TMCB (Ethyl Corporation, unpublished data)
- Characteristics of the General Toxic, Gonadatropic, and Mutagenic Effects of 1,3-chlorobromopropane (Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv)

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Effects on respiratory irritation: irritating

Justification for classification or non-classification

Under the experimental conditions, 1-bromo-3-chloropropane does require labelling with the hazard statement H335 "May cause respiratory irritation" in accordance with the CLP regulation.