(4'-methyl-3-fluoro[1,1'-biphenyl]-4-yl)-boronic acid

Surface tension

Link to relevant study record(s)

Reference

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March 17, 2018 - March 20, 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Version / remarks:

2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

ring method

Key result

Surface tension:

71.6 mN/m

Temp.:

20 °C

Conc.:

4 mg/L

Remarks on result:

other: The test item was not completely solved. Therefore, the solution was filtered and diluted to 90%.

Preliminary test

4.0 mg of the test item were put into 1000 ml with demineralized water and stirred at ambient temperature for approx. 3 days. The test item was not completely solved after the stirring period. Therefore, the solution was filtered and diluted to 90 %. After adapting to 20 °C the measurement of the surface tension with the test item was carried out at 20 +/- 0.5 °C (20.2 °C), as follows:

The solution to be measured was transferred to the measurement vessel, taking care to avoid foaming. The measurement vessel was placed on the table of the test apparatus. The measurement vessel was raised until the ring was immersed below the surface of the solution. The time from starting the measurement was recorded (see Table 1 below). Subsequently, the table top was lowered gradually and evenly at a rate of 0.3 cm/min to detach the ring from the surface until the maximum force was reached. The force was read on the tensiometer. The measurements were repeated until 6 measurements were within the limits of the stability criterion.

 

Table 1: Surface tension

Measurement	1	2	3	4	5	6
Time (s)	14	136	257	379	500	622
σ (mN/m) uncorrected	77.07	77.08	77.15	77.10	77.13	77.13
σ (mN/m) corrected according to Zuidema and Waters	71.56	71.57	71.65	71.60	71.62	71.62

Mean value: σ = 71.6 mN/m (corrected according to Zuidema and Waters)

The aqueous solution of the test item had a mean surface tension of 71.6 mN/m. As the surface tension was higher than 60 mN/m, the test item had no surface-active properties. 

Conclusions:

The surface tension of the aqueous solution at 20 °C had a mean value of 71.6 mN/m. The test item had no surface-active properties.

Executive summary:

The purpose of this study was the determination of the surface tension of the test item according to EU Method A.5 and OECD Guideline 115. The sample was tested as received. No preliminary treatment such as drying or milling was performed. The aqueous solution of the test item had a mean surface tension of 71.6 mN/m. As the surface tension was higher than 60 mN/m, the test item had no surface-active properties.

Description of key information

The surface tension of the aqueous solution at 20 °C had a mean value of 71.6 mN/m. The test item had no surface-active properties.

Additional information

The purpose of this study was the determination of the surface tension of the test item according to EU Method A.5 and OECD Guideline 115. The sample was tested as received. No preliminary treatment such as drying or milling was performed. The aqueous solution of the test item had a mean surface tension of 71.6 mN/m. As the surface tension was higher than 60 mN/m, the test item had no surface-active properties.