Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07.09.2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
(4'-methyl-3-fluoro[1,1'-biphenyl]-4-yl)-boronic acid
EC Number:
813-651-8
Cas Number:
1698890-39-9
Molecular formula:
C13H12BFO2
IUPAC Name:
(4'-methyl-3-fluoro[1,1'-biphenyl]-4-yl)-boronic acid
Test material form:
solid

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
3.8
Temp.:
25 °C
pH:
6

Applicant's summary and conclusion

Executive summary:

The logPOW of the test substance was determined according to the HPLC method and was found to be 3.8.