Registration Dossier
Registration Dossier
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EC number: 216-322-1 | CAS number: 1559-34-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
QSAR (96hr LD50) = 22000mg/L.
Information from the source substances supported by the QSAR provides strong evidence that a concentration of 2000 mg/L of the substance will not cause any lethality to fish
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2 000 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- ng/L
Additional information
A reliable QSAR predicts a decrease in toxicity with increasing number of ethylene oxide units. The QSAR predicts that LC50 effectively doubles for every additonal EO group added to the molecule, therefore TEGBE can be assumed to have the lowest LC50.
In a guideline (OECD 203) GLP study modified to marine conditions, the 96 -hour LC50 of fish was examined using a commercial substance that was similar to the multi-constituent substance TEGBE-TetraEGBE (~2:1 ratio) but with higher than usual amounts of PentaEGBE . No deaths occured at the maximum tested concentration of 1800mg/L.
In a guideline acute fish toxicity study in freshwater, Leuciscus idus were exposed to the test substance TEGBE at concentrations up to 10000mg/l for a period of 96 hours. Because of the mortality profile, it was not possible to determine an exact LD50, only a range. The LD0 was 2150mg/l whilst the LD100 was 4640mg/l..
It can be predicted with confidence that the LC50 substance TetraEGBE will be in excess of 2000mg/L.
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