5'-O-[bis(4-methoxyphenyl)benzyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)guanosine

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-10-20 to 2018-02-12

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

GLP compliance:

no

Type of method:

effusion method: vapour pressure balance

Temp.:

20 °C

Vapour pressure:

0 Pa

Temp.:

25 °C

Vapour pressure:

0.001 Pa

Temp.:

50 °C

Vapour pressure:

0.002 Pa

The vapour pressure was measured in the temperature range of 30 °C to 90 °C, chosen according to the temperatures for which results are to be reported, ending below the melting point of the test item. The mass of the test item was determined before (0.4389 g) and after (0.4148 g) the vapour pressure measurement. A mass loss of approximately 5% (w/w) was determined.

Table 1: Measured vapour pressures and corresponding temperatures

Temperature / °C	Vapour pressure / hPa
30	5.9 x 10E-6
40	1.3 x 10E-5
50	2.4 x 10E-5
60	4.2 x 10E-5
70	6.5 x 10E-5
80	8.8 x 10E-5
90	4.8 x 10E-5

The data point measured at 30 °C was not included in the linear regression because it was below the detection limit of the applied method. Above 80 °C the vapour pressure started to decrease and therefore the value at 90 °C was not used in the linear regression. The values for 20, 25 and 50 °C are calculated using the Antoine constants.

Conclusions:

The vapour pressure of the test item was determined according to the OECD guideline 104 by effusion method using a vapour pressure balance. The vapour pressure was measured in the temperature range of 30 °C to 90 °C. The following vapour pressures were interpolated for 50 °C and extrapolated for 20 °C and 25 °C from the experimental data:
20 °C: 4.3 x 10E-4 Pa
25 °C: 5.9 x 10E-4 Pa
50 °C: 2.3 x 10E-3 Pa

Executive summary:

The vapour pressure of the test item was determined according to the OECD guideline 104 by effusion method using a vapour pressure balance. The vapour pressure was measured in the temperature range of 30 °C to 90 °C. The following vapour pressures were interpolated for 50 °C and extrapolated for 20 °C and 25 °C from the experimental data:

20 °C: 4.3 x 10E-4 Pa

25 °C: 5.9 x 10E-4 Pa

50 °C: 2.3 x 10E-3 Pa

Description of key information

The vapour pressure of the test item was determined according to the OECD guideline 104 by effusion method using a vapour pressure balance. The vapour pressure was measured in the temperature range of 30 °C to 90 °C. The following vapour pressures were interpolated for 50 °C and extrapolated for 20 °C and 25 °C from the experimental data:

20 °C: 4.3 x 10E-4 Pa

25 °C: 5.9 x 10E-4 Pa

50 °C: 2.3 x 10E-3 Pa