2-hydroxycyclohepta-2,4,6-trienone

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

20 to 24 February 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Remarks:

Staatliches Gewerbeaufsichtsamt Hildesheim, Germany

Type of method:

flask method

Key result

Water solubility:

35.3 g/L

Incubation duration:

>= 24 - <= 72 h

Temp.:

20 °C

pH:

4.1

The following table reports the results of the water solubility test.

 

Preincubation time	Replicate No.	Concentration [g/L] *	Mean [g/L]
24 h	1	35.1	35.5
	2	35.9
48 h	1	34.7	35.1
	2	35.4
72 h	1	35.9	35.2
	2	34.4
Mean (24 - 72 h)			35.3
Deviation [%] (24 - 72 h)			1.3

* Mean value of two injections, dilution factor of 333.3 and exact weight of the standard taken into account

 

The temperature during the pre-incubation and the thermostatisation phase resulted to be 30.06 ± 0.09 °C and 20.00 ± 0.05 °C, respectively.

 

A mean pH-value of 4.1 was determined with the remaining test item mixtures in the original test vessels, which were kept constant at 20 ± 0.5 °C.

 

The test samples showed no Tyndall-Effect.

 

 

Conclusions

The solubility of the test item was determined at 20 ± 0.5 °C to be 35.3 g/L (pH 4.1).

Conclusions:

A water solubility value of 35.3 g/L (at 20 °C, pH = 4.1) was determined for the test substance according to OECD 105.

Description of key information

Water solubility: 35.2 g/L at 20 °C, pH 4.1 (EU Method A.6., flask method)

Key value for chemical safety assessment

Water solubility:

35.2 g/L

at the temperature of:

20 °C