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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1955
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation

Data source

Reference
Reference Type:
publication
Title:
Report on Monuron, EPA Pesticide Petition
Author:
Zapp, J.A.
Year:
1955
Bibliographic source:
EPA Pesticide Petition, n17, vol II

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
not specified
Type of study:
not specified

Test material

Reference
Name:
Unnamed
Specific details on test material used for the study:
FORM AS APPLIED IN THE TEST 33% water paste

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
male

Study design: in vivo (non-LLNA)

Challenge
Route:
other: intact and abraded skin
Vehicle:
water
Adequacy of challenge:
not specified
Positive control substance(s):
not specified

Results and discussion

In vivo (non-LLNA)

Results
Group:
test group
Dose level:
33%
Remarks on result:
other: no details available

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
The compound was practically nonirritanting an did not cause allergic skin.
Executive summary:

This guinea pig study was carried out to evaluate the Primary Irritation and Skin Sensitization of Monuron. A 33% water paste of monuron was applied to both intact and abraded skin of male albino guinea pigs. The compound was practically non irritating and did not cause allergic skin sensitization. No further details were given on such parameters as numbers used or period of experimentation. The author concluded that a moderate amount of skin contact with Monuron would not be harmful because it is not an irritant or a sensitizer, nor is it significantly absorbed through the skin (Zapp, 1955) .